| Curative effect of Ziyin Huatan Recipe combined with chemotherapy on advanced gastric cancer |
| Received:July 04, 2021 Revised:September 04, 2021 Click here to download the full text |
| Citation of this paper:WANG Xiao-wei,YUE Xiao-qiang.Curative effect of Ziyin Huatan Recipe combined with chemotherapy on advanced gastric cancer[J].Chinese Journal of Clinical Medicine,2021,28(6):1005-1010 |
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| Abstract:Objective: To explore the clinical curative effect of Ziyin Huatan Recipe combined with chemotherapy on advanced gastric cancer.Methods: The patients with advanced gastric cancer of stasis-phlegm syndrome were enrolled as the research objects from March 2011 to October 2017. They were divided into chemotherapy group and integrated traditional Chinese and Western medicine group (integrated group) by random number table method, 40 cases in each group. In chemotherapy group, SOX regimen was applied firstly, after completing 2 cycles of treatment, the patients with advanced disease switched to tegafur gimeracil oteracil potassium capsule(S-1)+ docetaxel or CapeOX based regimen treatment. The integrated group was additionally treated with Ziyin Huatan Recipe. The disease control rate (DCR) and objective response rate (RR), scores of TCM syndromes and Karnofsky performance status (KPS) before and after treatment were compared between the two groups. Changes in levels of immune function indexes and tumor inflammatory factors before and after treatment in both groups were observed.The survival status of patients was statistically analyzed. Results: RR in integrated group was higher than that in chemotherapy group (P<0.05). There was no significant difference in DCR between the two groups. After treatment, scores of TCM syndromes in integrated group was lower than those in chemotherapy group, while KPS score was higher than that in chemotherapy group (P<0.05). After treatment, levels of hypoxia inducible factor-1α (HIF-1α), tumor necrosis factor-α (TNF-α), interleukin-10 (IL-10) and monocyte chemoattractant protein-1 (MCP-1) were lower than those in chemotherapy group (P<0.05). After treatment, CD3+, CD4+ and CD4+/CD8+ in integrated group were higher than those in chemotherapy group (P<0.05). There was no significant difference in 1-year, 2-year and 3-year survival rates between the two groups. The median OS in integrated group and chemotherapy group was 20.15 months and 16.7 months, respectively.Conclusions: Ziyin Huatan recipe combined with chemotherapy can not only improve clinical effect and immune function, relieve inflammation response, but also improve quality of life, prolong survival of patients with advanced gastric cancer. |
| keywords:Ziyin Huatan Recipe integrated treatment of traditional Chinese and Western medicine advanced gastric cancer clinical effect |
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