| Clinical efficiency of frontline RCHOP regimen in treatment of follicular lymphoma grade 3 patients with different histological subtypes |
| Received:April 11, 2021 Revised:July 14, 2021 Click here to download the full text |
| Citation of this paper:CHEN Fei-fei,AZIGULI Maihemaiti,WEI Zheng,CHENG Lu-ya,WANG Wei-guang,ZHUANG Jing-li,YUAN Ling,CHENG Zhi-xiang,WANG Zhi-mei,JI Li-li,GE Xiao-wen,LIU Peng.Clinical efficiency of frontline RCHOP regimen in treatment of follicular lymphoma grade 3 patients with different histological subtypes[J].Chinese Journal of Clinical Medicine,2021,28(6):988-992 |
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| Author Name | Affiliation | E-mail | | CHEN Fei-fei | Department of Hematology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | AZIGULI Maihemaiti | Department of Hematology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Department of Lymphoma Medicine, Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi 830000, Xinjiang Uygur Autonomous Region, China | | | WEI Zheng | Department of Hematology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | CHENG Lu-ya | Department of Hematology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | WANG Wei-guang | Department of Hematology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | ZHUANG Jing-li | Department of Hematology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | YUAN Ling | Department of Hematology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | CHENG Zhi-xiang | Department of Hematology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | WANG Zhi-mei | Department of Hematology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | JI Li-li | Department of Hematology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | GE Xiao-wen | Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | LIU Peng | Department of Hematology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | liu.peng@zs-hospital.sh.cn |
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| Abstract:Objective: To explore the clinical features and outcomes of follicular lymphoma (FL) grade 3 treated with frontline RCHOP regimen.Methods: 61 FL grade 3 patients treated with frontline RCHOP regimen between January 2009 and December 2019 were retrospectively analyzed. We divided them into FL grade 3A (n=42) and aggressive FL (n=19). Aggressive FL included grade 3A with an additional 3B component (n=2), grade 3B (n=8), and grade 3 with areas of diffuse large B cell lymphoma (n=9).Results: The baseline characteristics, including gender, age, serum β2 microglobulin and lactate dehydrogenase levels, Ann Arbor stage, B symptom and bone marrow involvement were similar between FL grade 3A and aggressive FL. After a median follow-up period of 40.2 months, the 3-year overall survival (OS) rate was 97.1% in FL grade 3A and 81.9% in aggressive FL, (P=0.041). The 3-year progression free survival (PFS) rate was 69.1% and 71.1%, respectively, (P=0.546). Patients of aggressive FL reached a plateau in the PFS curve after 2 years.Conclusions: The 3-year OS survival rate of the frontline RCHOP regimen in the treatment of FL3A patients was better than that of aggressive FL, but the PFS difference between the two was not statistically significant. PFS plateau appears after 2 years of treatment in aggressive FL patients. |
| keywords:follicular lymphoma RCHOP clinical features survival |
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