| Analysis of clinical using time difference of different dosage forms of fluorouracil injection with portable infusion pump |
| Received:March 15, 2021 Revised:May 08, 2021 Click here to download the full text |
| Citation of this paper:WENG Jing-yan,ZHANG Jian-zhong,XU Gen-ying.Analysis of clinical using time difference of different dosage forms of fluorouracil injection with portable infusion pump[J].Chinese Journal of Clinical Medicine,2021,28(3):428-432 |
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| Author Name | Affiliation | E-mail | | WENG Jing-yan | Department of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | ZHANG Jian-zhong | Department of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai 200032, China | zhang.jianzhong@zs-hospital.sh.cn | | XU Gen-ying | Department of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai 200032, China | xu.genying@zs-hospital.sh.cn |
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| Abstract:Objective: To explore the difference of clinical using time of fluorouracil powder and injection in portable infusion pump, and analyze the reasons, so as to guide clinical medication. Methods: Under ideal laboratory conditions and filtering or no filtering, the infusion time, osmotic pressure, pH value, clarity and content of fluorouracil injection and fluorouracil powder in portable infusion pump were determined, which may affect the flow rate of pharmaceutical properties. Results: Compared with the continuous infusion of different fluorouracil powder injection and fluorouracil injection using portable infusion pump, fluorouracil powder injection has prolonged the infusion time. And different brand powder injection also has bigger difference, such as fluorouracil A 57 h, fluorouracil B 90 h, this is consistent with clinical use. Before the liquid was filtered, the clinical infusion speed of the two kinds of fluorouracil powder was significantly different. However, after filtration, the infusion speed of the two kinds of fluorouracil powder was basically the same as that of fluorouracil injection, and there was no significant difference in drug concentration, osmotic pressure, and pH value. Combined with the clarity test results of the drug solution, the main factor affecting the infusion time of fluorouracil powder injection in the portable infusion pump is the presence of non-drug active excipients in the preparation. Conclusions: The infusion speed of fluorouracil powder and injection in the clinical use of portable infusion pump is significantly different. The main reason for the difference in the clinical use of fluorouracil powder from different manufacturers is the difference in preparation and excipients, which suggests that attention should be paid to clinical use. |
| keywords:fluorouracil powder injection fluorouracil injection portable infusion pump differences in clinical using time |
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