| Clinical characteristics and prognostic factors in patients with lung cancer complicated with venous thromboembolism |
| Received:March 12, 2021 Revised:April 06, 2021 Click here to download the full text |
| Citation of this paper:WANG A-man,FANG Feng-qi,LI Jia,LIU Ying,XIA Yun-long,LIU Ji-wei.Clinical characteristics and prognostic factors in patients with lung cancer complicated with venous thromboembolism[J].Chinese Journal of Clinical Medicine,2021,28(2):164-168 |
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| Author Name | Affiliation | E-mail | | WANG A-man | Department of Oncology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning, China | | | FANG Feng-qi | Department of Oncology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning, China | | | LI Jia | Department of Oncology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning, China | | | LIU Ying | Department of Cardiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning, China | | | XIA Yun-long | Department of Cardiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning, China | | | LIU Ji-wei | Department of Oncology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning, China | jiweiliudl@126.com |
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| Abstract:Objective: To explore the clinical characteristics, treatment modes, outcomes, and risk factors in lung cancer patients with venous thromboembolism (VTE).Methods: The date of 5 769 lung cancer patients admitted in the First Affiliated Hospital of Dalian Medical University between Jan 1, 2015 and Dec 31, 2020 were retrospectively analyzed, and the patients with VTE were collected. Clinical data such as sex, age, smoking history, clinical stage, and histopathologic type were collected. The incidence, clinical characteristics, timing, and influencing factors of VTE in patients with lung cancer were analyzed.Results: The incidence of VTE in lung cancer patients was 1.3% (76/5 769); the median age was 69 years. male accounted for 47.4%; female accounted for 52.6%. 28.9% had smoking history, 25.0% had surgical history, 69.7% had basic disease. The chinical stage Ⅰ-Ⅲ, 47.4%, stage Ⅳ, 52.6%; adenocarcinoma, 76.3%; drive gene mutation, 18.4%. ECOG score at diagnosis of lung cancer in 84.2% patients was 0-2 points. 89.5% patients were in the middle-risk of Khorana score at diagnosis of lung cancer and 10.5% were in the high-risk. 36.8% had deep venous thrombosis, 32.9% had pulmonary embolism, and 30.3% had deep venous thrombosis combined with pulmonary embolism. In the VTE patients, D-dimer was 100-29 900 μg/L, with a median of 4 100 μg/L, and 94.7% patients increased. 30.3% of VTE occurred during tumor treatment. 42.9%(12/28) patients had VTE within 90 days after surgery, and the risk was the highest within 30 days after surgery. VTE occurred in 55.0%(22/40) patients with advanced lung cancer within 9 months of diagnosis, especially within 3 months. 92.1% received anticoagulant therapy; 93.4% improved after treatment, and 6.6% died due to VTE. The smoking history and ECOG score at the diagnosis of lung cancer were correlated with the outcome of VTE (P<0.05).Conclusions: The patients with lung cancer may complicated with VTE, and the clinical characteristics in the patiens are complex. It is necessary to pay attention to the prevention, evaluation, and screening of VTE in perioperative and advanced metastatic patients. |
| keywords:lung cancer venous thromboembolism outcome |
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