| Prediction value of sST2 for the prognosis of patients with immune checkpoint inhibitor-associated myocarditis |
| Received:February 28, 2021 Revised:April 07, 2021 Click here to download the full text |
| Citation of this paper:LI Zheng,WANG Yan,LIN Jin-yi,ZHAO Shi-hai,CHEN Jia-hui,ZHOU Yu-hong,LIU Tian-shu,DAN Bing,CHENG Lei-lei.Prediction value of sST2 for the prognosis of patients with immune checkpoint inhibitor-associated myocarditis[J].Chinese Journal of Clinical Medicine,2021,28(2):159-163 |
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| Author Name | Affiliation | E-mail | | LI Zheng | Department of Echocardiography, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China
Shanghai Institute of Medical Imaging, Shanghai 200032, China | | | WANG Yan | Department of Medical Oncology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | LIN Jin-yi | Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China
Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | ZHAO Shi-hai | Department of Radiodiagnosis, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | CHEN Jia-hui | Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China
Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | ZHOU Yu-hong | Department of Medical Oncology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | LIU Tian-shu | Department of Medical Oncology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | DAN Bing | Department of Medical Oncology, Dunfu Hospital, Shanghai 200032, China | | | CHENG Lei-lei | Department of Echocardiography, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China
Shanghai Institute of Medical Imaging, Shanghai 200032, China | cheng.leilei@zs-hospital.sh.cn |
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| Abstract:Objective: To investigate the prognostic value of soluble growth stimulation expressed gene 2 protein (sST2) in patients with immune checkpoint inhibitor-associated myocarditis (ICIAM).Methods: From January 1, 2019 to December 31, 2020, 19 patients with ICIAM were selected from Cardio-oncology multidisciplinary team of Zhongshan Hospital, Fudan University. According to the prognosis, they were divided into the survival group (n=15) and the death group (n=4). Receiver operating characteristic (ROC) curve was used to analyze the predictive value of sST2 level for prognosis.Results: The peak concentration of sST2 in the death group was higher than that in the survival group during the treatment (156.50[91.60, 410.60] ng/mL vs 54.65[18.20, 97.40] ng/mL, P=0.014), and there was no significant difference in other indexes. The peak concentration of sST2 was negatively correlated with survival (r=-0.683, P=0.010). ROC analysis showed that when sST2 level was 87.5 ng/mL, area under the curve (AUC) was 0.967, sensitivity was 90.0%, and specificity was 100.0%.Conclusions: sST2 could predict the prognosis of patients with ICIAM, and could help to make and improve the treatment of patients with ICIAM. |
| keywords:soluble growth stimulation expressed gene 2 protein immune checkpoint inhibitor myocarditis |
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