| Analysis of value of urine soluble CD163 in predicting crescent formation in IgA nephropathy |
| Received:February 24, 2021 Revised:March 12, 2021 Click here to download the full text |
| Citation of this paper:GONG Shao-min,JIN Shi,SHI Yi-qin,SHEN Zi-yan,LIU Hong,DING Xiao-qiang.Analysis of value of urine soluble CD163 in predicting crescent formation in IgA nephropathy[J].Chinese Journal of Clinical Medicine,2021,28(2):210-215 |
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| Author Name | Affiliation | E-mail | | GONG Shao-min | Department of Nephrology, Zhongshan Hospital, Fudan University
China Shanghai Institute of Kidney and Dialysis
Shanghai Key Laboratory of Kidney and Blood Purification, Shanghai 200032 | | | JIN Shi | Department of Nephrology, Zhongshan Hospital, Fudan University
China Shanghai Institute of Kidney and Dialysis
Shanghai Key Laboratory of Kidney and Blood Purification, Shanghai 200032 | | | SHI Yi-qin | Department of Nephrology, Zhongshan Hospital, Fudan University
China Shanghai Institute of Kidney and Dialysis
Shanghai Key Laboratory of Kidney and Blood Purification, Shanghai 200032 | | | SHEN Zi-yan | Department of Nephrology, Zhongshan Hospital, Fudan University
China Shanghai Institute of Kidney and Dialysis
Shanghai Key Laboratory of Kidney and Blood Purification, Shanghai 200032 | | | LIU Hong | Department of Nephrology, Zhongshan Hospital, Fudan University
China Shanghai Institute of Kidney and Dialysis
Shanghai Key Laboratory of Kidney and Blood Purification, Shanghai 200032 | | | DING Xiao-qiang | Department of Nephrology, Zhongshan Hospital, Fudan University
China Shanghai Institute of Kidney and Dialysis
Shanghai Key Laboratory of Kidney and Blood Purification, Shanghai 200032 | ding.xiaoqiang@zs-hospital.sh.cn |
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| Abstract:Objective: To explore the value of urine soluble CD163 in predicting crescent formation in IgA nephropathy.Methods: A retrospective study was conducted in patients with renal biopsy-proven primary IgA nephropathy who were admitted to Zhongshan Hospital, Fudan University from January 2018 to December 2019. Patients who had hepatitis, autoimmune diseases, or received immunosuppressive agents less than 3 months prior to the renal biopsy were excluded. According to the 2016 Oxford classification of IgA nephropathy, patients were divided into the crescents free group and the crescents formation group. The concentration of urine soluble CD163 adjusted by urine creatinine in urine before the biopsy, and its correlation with clinical and laboratory data were analyzed.Results: Totally, 358 patients were analyzed, including 218 cases (60.9%) in the crescents free group and 140 cases (39.1%) in the crescents formation group. The concentration of urine soluble CD163 was significantly higher in the crescents formation group[(6.72±10.90) ng/mg vs (3.54±6.72) ng/mg, P<0.001]. Urine sCD163 concentration was positively correlated with 24-hour urine protein quantification (r=0.593, P<0.001) and crescent ratio (r=0.274, P=0.001), and was negatively correlated with renal function (r=-0.241, P<0.001). In the subgroup of patients with proteinuria <1 g/24 h and eGFR ≥ 30 mL·min-1·(1.73 m2)-1 with crescent formation, the urine sCD163 concentration was significantly increased (P<0.05). The area under the ROC of the urine sCD163 concentration for judging crescent formation was 0.715 which was higher than that of eGFR (0.569, P<0.000 1).Conclusions: Urine sCD163 concentration maybe increased significantly in IgA nephropathy patients with crescent formation which is closely related to the proteinuria, eGFR, and crescent ration. It may have a better performance in predicting the crescent formation in IgA nephropathy than that of proteinuria and eGFR, especially in patients with mild clinical manifestation. |
| keywords:soluble CD163 IgA nephropathy crescent renal pathology |
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