| Noninvasive evaluation of hemodynamic changes of myocardial bridge using coronary CTA and computational fluid dynamics |
| Received:February 09, 2021 Revised:March 17, 2021 Click here to download the full text |
| Citation of this paper:LU Yi-han,YU Meng-meng,ZENG Meng-su,ZHOU Guo-feng.Noninvasive evaluation of hemodynamic changes of myocardial bridge using coronary CTA and computational fluid dynamics[J].Chinese Journal of Clinical Medicine,2021,28(3):396-401 |
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| Author Name | Affiliation | E-mail | | LU Yi-han | Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Shanghai Institute of Medical Imaging, Shanghai 200032, China | | | YU Meng-meng | Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Shanghai Institute of Medical Imaging, Shanghai 200032, China | | | ZENG Meng-su | Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Shanghai Institute of Medical Imaging, Shanghai 200032, China | | | ZHOU Guo-feng | Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Shanghai Institute of Medical Imaging, Shanghai 200032, China | zhou.guofeng@zs-hospital.sh.cn |
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| Abstract:Objective: To explore the effect of myocardial bridge (MB) on non-invasive fractional flow reserve (FFRCT) and wall shear stress (WSS) using coronary CT angiography (CTA) and computational fluid dynamics (CFD). Methods: From May 2020 to December 2020, 50 patients with MB in left anterior descending artery and 25 controls undergoing coronary CTA in Zhongshan Hospital, Fudan University were included. Patients were divided into superficial (n=25) and deep MB groups (n=25) according to the depth of MB. The differences in anatomical characteristics, FFRCT values, and WSS values among groups were analyzed. The MB group was divided into normal FFRCT (>0.8) and abnormal FFRCT (≤ 0.8) groups according to FFRCT values. The differences in clinical symptoms, anatomical characteristics, and WSS values between the two groups were analyzed. Results: Compared to control group, the FFRCT values of superficial and deep MB groups decreased in diastolic phase and systolic phase (P<0.001); the WSS values of coronary artery distal to MB were higher in superficial and deep groups in both phases (P=0.037, 0.002). A significant difference in systolic MB compression index was found between normal FFRCT and abnormal FFRCT groups (P=0.023). Patients with abnormal FFRCT were more likely to have angina (30.8% vs 8.3%, P=0.048). Conclusions: The FFRCT values of MB patients are lower than those of controls. The WWS values of coronary artery distal to MB are higher than those of controls. The increase of systolic myocardial bridge compression index has a association with the decrease of FFRCT values. Patients with abnormal FFRCT values are more likely to have angina. |
| keywords:myocardial bridge coronary CT angiography computational fluid dynamics fractional flow reserve wall shear stress |
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