| Research progress of NLRP3 inflammasome as a potential therapeutic target for kidney disease |
| Received:January 22, 2021 Revised:March 23, 2021 Click here to download the full text |
| Citation of this paper:ZHAO Ting,ZHANG Fang-fei,WANG Nian-song,WANG Feng.Research progress of NLRP3 inflammasome as a potential therapeutic target for kidney disease[J].Chinese Journal of Clinical Medicine,2022,29(4):685-695 |
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| Author Name | Affiliation | E-mail | | ZHAO Ting | Department of Nephrology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China | | | ZHANG Fang-fei | Department of Nephrology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China | | | WANG Nian-song | Department of Nephrology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China | | | WANG Feng | Department of Nephrology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China | zyzwq1030@163.com |
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| Abstract:Plenty of evidence suggested an association between kidney disease and inflammasomes, especially nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasomes. NLRP3 inflammasomes play an important role in renal inflammation and fibrosis. Small molecule inhibitors targeting the components of NLRP3 inflammasomes are potential options for the treatment of kidney-related diseases. This article reviews the new findings of the role of NLRP3 inflammasomes in kidney disease in recent years and new strategies targeting NLRP3 inflammasomes. |
| keywords:NLRP3 inflammasome kidney disease acute kidney injury chronic kidney disease |
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