| Association between IL-1β gene polymorphism and susceptibility to Henoch-Schönlein purpura nephritis in children |
| Received:December 21, 2020 Revised:January 14, 2021 Click here to download the full text |
| Citation of this paper:QU Feng-xiang,CHANG Hong,LIN Yi,WANG Fang,WANG Jia-lan.Association between IL-1β gene polymorphism and susceptibility to Henoch-Schönlein purpura nephritis in children[J].Chinese Journal of Clinical Medicine,2021,28(2):273-277 |
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| Author Name | Affiliation | E-mail | | QU Feng-xiang | Department of Pediatrics, Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong, China | | | CHANG Hong | Department of Pediatrics, Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong, China | 18661802671@yeah.net | | LIN Yi | Department of Pediatrics, Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong, China | | | WANG Fang | Department of Pediatrics, Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong, China | | | WANG Jia-lan | Department of Pediatrics, Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong, China | |
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| Abstract:Objective: To investigate the relationship between single nucleotide polymorphism of interleukin-1β (IL-1β) gene and susceptibility to Henoch-Schönlein purpura and Henoch-Schönlein purpura nephritis in children.Methods: A total of 174 children with Henoch-Schönlein purpura were selected as the case group, and 162 healthy children who underwent physical examination at the same time were selected as the control group. According to their clinical symptoms, patients were divided into the simple group, joint group, abdominal group, and mixed groups. According to whether complicated with renal damage during the follow-up, patients were divided into non-nephritis group and nephritis group. The rs1143627 locus of the IL-1β gene was targeted and captured by the M-PCR method. All samples were sequenced by the high-throughput sequencing technique, and the correlations of the sequencing data and the different groups were analyzed.Results: There was no significant difference in rs1143627 genotype and allele among different clinical symptom groups, but there were significant differences in rs1143627 genotype GG and allele G between the case group and control group, and the non-nephritis group and nephritis group.Conclusions: rs1143627 gene polymorphism is associated with Henoch-Schönlein purpura and renal involvement. Allele G may be the susceptible gene of Henoch-Schönlein purpura and is related to the occurrence of Henoch-Schönle purpura nephritis in children. |
| keywords:interleukin-1β gene polymorphism children Henoch-Schönlein purpura Henoch-Schönlein purpura nephritis |
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