| Clinical and electrophysiological characteristics of subacute combined degeneration of the spinal cord |
| Received:December 18, 2020 Revised:March 22, 2021 Click here to download the full text |
| Citation of this paper:ZHOU Ying,SHAO Zhi-hai,DONG Ji-hong,FEI Guo-qiang.Clinical and electrophysiological characteristics of subacute combined degeneration of the spinal cord[J].Chinese Journal of Clinical Medicine,2021,28(3):460-464 |
| Hits: 1064 |
| Download times: 398 |
| Author Name | Affiliation | E-mail | | ZHOU Ying | Department of Neurology, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen 361000, Fujian, China | | | SHAO Zhi-hai | Department of Neurology, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen 361000, Fujian, China | | | DONG Ji-hong | Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | FEI Guo-qiang | Department of Neurology, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen 361000, Fujian, China
Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | fei.guoqiang@zs-hospital.sh.cn |
|
| Abstract:Objective: To explore the clinical and electrophysiological characteristics of patients with subacute combined degeneration of spinal cord (SCD). Methods: The clinical manifestations, laboratory examination results, electrophysiological characteristics, and MRI and follow-up data of 12 SCD patients diagnosed and treated in the Xiamen Branch, Zhongshan Hospital, Fudan University from January 2018 to March 2020 were retrospectively analyzed. Results: Of the 12 patients, 5 had a history of total gastrectomy, 3 had chronic superficial gastritis, 3 had a long-term vegetarian history, 1 had a long-term drinking history; 9 had limb numbness, 12 had unsteady walking, 10 had sensation signs, 12 had Romberg sign, 6 had pathologic reflexes; 9 had megaloblastic anemia, 11 had plasma vitamin B12 deficiency, 1 had folic acid deficiency, 12 had homocysteine increased; 9 had T2 hyperintensity in the spinal cord and 11 had abnormal electrophysiological manifestation. All patients were treated with vitamin B12 or mecobalamin, and the clinical symptoms were improved after treatment. Conclusions: Vitamin B12 deficiency is the main cause of SCD. For people with a history of gastric disease, long-term drinking, and long-term vegetarian diet, combined blood routine test, vitamin B12, homocysteine, electrophysiological examination, and cervical and thoracic magnetic resonance imaging are helpful to improve the diagnosis rate of SCD. Early diagnosis and early vitamin B12 treatment can help improve SCD symptoms. |
| keywords:subacute combined degeneration of the spinal cord vitamin B12 deficiency homocysteine electrophysiology |
| HTML View Full Text View/Add Comment Download reader |
|
|
|