| Advances of detecting methods of carbapenem-resistant Enterobacteriales genotyping |
| Received:December 11, 2020 Revised:March 24, 2022 Click here to download the full text |
| Citation of this paper:CAO Jin-nan,HUANG Sheng-lei,ZHOU Chun-mei,GUO Wei.Advances of detecting methods of carbapenem-resistant Enterobacteriales genotyping[J].Chinese Journal of Clinical Medicine,2022,29(6):1052-1058 |
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| Author Name | Affiliation | E-mail | | CAO Jin-nan | Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | HUANG Sheng-lei | Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | ZHOU Chun-mei | Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | GUO Wei | Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China | guo.wei@zs-hospital.sh.cn |
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| Abstract:It has been reported in the literatures that infections caused by carbapenem-resistant Enterobacteriaceae (CRE), especially bloodstream infections, can lead to higher patient mortality and bring great challenges to clinical treatment. At present, there are only a few new antibacterial drugs that can be used for the treatment of CRE, such as ceftazidime-avibactam, but ceftazidime-avibactam has no activity on CRE with metal β-lactamase, so it is very important that the CRE strain be detected quickly and accurately. At present, the detecting methods of carbapenem-resistant Enterobacteriaceae genotype include phenotypic methods, molecular bioloy, and mass spectrometry. This review summarizes and analyzes the advantages and disadvantages of these methods. |
| keywords:Enterobacter bacteria carbapenemase resistance genotyping |
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