| Changes of plasma Clara cell secretory protein level and its relationship with arterial blood gas in patients with chronic obstructive pulmonary disease |
| Received:November 10, 2020 Revised:January 18, 2021 Click here to download the full text |
| Citation of this paper:YAN Jun,SHI Bao-ping,CHENG Ke-wen,SU Jian-hua.Changes of plasma Clara cell secretory protein level and its relationship with arterial blood gas in patients with chronic obstructive pulmonary disease[J].Chinese Journal of Clinical Medicine,2021,28(6):1011-1015 |
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| Author Name | Affiliation | E-mail | | YAN Jun | Department of Respiratory and Critical Care Medicine, Renhe Hospital, Baoshan District, Shanghai 200431, China | | | SHI Bao-ping | Department of Respiratory and Critical Care Medicine, Renhe Hospital, Baoshan District, Shanghai 200431, China | 18930844975@163.com | | CHENG Ke-wen | Department of Respiratory and Critical Care Medicine, Renhe Hospital, Baoshan District, Shanghai 200431, China | | | SU Jian-hua | Department of Respiratory and Critical Care Medicine, Renhe Hospital, Baoshan District, Shanghai 200431, China | |
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| Abstract:Objective: To explore the changes of plasma Clara cell secretory protein (CC16) and its relationship with arterial blood gas in patients with chronic obstructive pulmonary disease (COPD). Methods: The clinical data of 94 COPD patients and 43 healthy people admitted to the Renhe Hospital of Baoshan District in Shanghai from March 2019 to June 2020 were retrospectively analyzed. Study subjects were divided into stable COPD group (n=49), acute exacerbation COPD group (n=45), and healthy group (n=43). The levels of plasma CC16 and arterial blood gas related parameters (arterial oxygen pH, arterial partial pressure of oxygen[PaO2], arterial partial pressure of carbon dioxide[PaCO2], arterial oxygen saturation[SaO2]) were compared among the three groups. Pearson correlation analysis was used to explore the correlation between the changes of plasma CC16 levels and arterial blood gas related parameters in COPD patients. Results: The levels of plasma CC16, pH, PaO2 and SaO2 in the healthy group were higher than those in the stable COPD group, and which in the stable COPD group were higher than those in the acute exacerbation COPD group, with statistically significant differences (P<0.05). The PaCO2 in the stable COPD group and the acute exacerbation COPD group were higher than that in the healthy group, and which in the acute exacerbation COPD group was higher than that in the stable COPD group (P<0.05). The levels of plasma CC16 were positively correlated with pH, PaO2, and SaO2 in the stable COPD group (r=0.752, 0.824, 0.874), the acute exacerbation COPD group (r=0.768, 0.856, 0.917), and COPD patients (r=0.759, 0.839, 0.887), whereas negatively correlated with PaCO2 (r=-0.819, -0.835, -0.820), all P<0.05. Conclusions: There are correlations between plasma CC16 levels and arterial blood gas parameters in stable and acute exacerbation COPD patients, and the changes in acute exacerbation COPD patients are significantly greater than those in stable COPD patients. |
| keywords:chronic obstructive pulmonary disease stable period acute exacerbation Clara cell secretory protein arterial blood gas |
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