| Analysis of food-borne antibiotic exposure in late pregnancy and its health effects |
| Received:November 08, 2020 Revised:March 08, 2021 Click here to download the full text |
| Citation of this paper:ZHANG Ya-wei,LI Jie-yan,ZHAO Rong,HAO Wen-jing,WANG Xin.Analysis of food-borne antibiotic exposure in late pregnancy and its health effects[J].Chinese Journal of Clinical Medicine,2021,28(4):670-674 |
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| Author Name | Affiliation | E-mail | | ZHANG Ya-wei | Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China | | | LI Jie-yan | Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China | | | ZHAO Rong | Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China | | | HAO Wen-jing | Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China | | | WANG Xin | Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China | wx1501@ccmu.edu.cn |
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| Abstract:Objective: To analyze the exposure of food-borne antibiotics to pregnant women and their newborns in the third trimester of pregnancy, and further explore the impact of food-borne antibiotics exposure on the infant intestinal microbiota. Methods: Totally, 86 pregnant women had regular obstetric examinations from May 2018 to December 2018 in Beijing Obstetrics and Gynecology Hospital, Capital Medical University were collected, they were divided into control group (n=43) and antibiotic exposure group (n=43) according to the antibiotic exposure in the neonatal cord blood samples. UPLC-MS/MS and TRFIA were used to detect the exposure of antibiotics to serum of pregnant women in the third trimester, umbilical cord serum, and neonatal feces. 16S rRNA second-generation sequencing platform was used to detect and analyze the infant intestinal microbiota. Results: The serum of pregnant women, umbilical cord serum, and neonatal feces results showed a high proportion of food-borne antibiotics exposure. There was a significant difference in infant intestinal microbiota between the antibiotic exposure group and the control group (P<0.05). Conclusions: Low-dose, continuous-exposure food-borne antibiotics can indirectly affect the infant intestinal microbiota through the mother and thus affect the health of infants and young children. |
| keywords:late pregnancy food-borne antibiotics intestinal microbiota |
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