| Research progress of GSDMD mediated pyroptosis in cardiovascular diseases |
| Received:October 11, 2020 Revised:March 18, 2021 Click here to download the full text |
| Citation of this paper:SHAN Shao-peng,LI Fang,HAO En-kui.Research progress of GSDMD mediated pyroptosis in cardiovascular diseases[J].Chinese Journal of Clinical Medicine,2022,29(2):267-272 |
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| Author Name | Affiliation | E-mail | | SHAN Shao-peng | Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China | | | LI Fang | Jinan Central Hospital, Jinan 250013, Shandong, China | | | HAO En-kui | Department of Cardiology, Qianfoshan Hospital, Shandong University, Jinan 250014, Shandong, China | haoenkui@sdu.edu.cn |
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| Abstract:Pyroptosis has been found to be one of the ways of cell death. Pyroptosis is closely related to the innate immune response of the body, which is characterized by the changes of cell membrane permeability and the release of inflammatory cytokines. Gasdermin D (GSDMD), as a key molecule in the process of pyroptosis, is activated by caspase to cleave into a pore-forming NH2- terminal cleavage product (GSDMD-NT) and an inhibitory COOH-terminal cleavage product (GSDMD-CT), and inflammatory cytokines are further released and inflammatory reactions are induced. At the same time, oxidative stress plays an important role in the regulation of pyroptosis. At present, more and more studies have found that pyroptosis plays an important role in the occurrence and development of cardiovascular diseases such as atherosclerosis, myocardial infarction, myocardial ischemia-reperfusion injury, myocarditis, cardiomyopathy, heart failure, and so on. |
| keywords:pyroptosis GSDMD oxidative stress cardiovascular diseases |
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