| The normal distribution characteristics of standardized uptake value of spine and pelvis with 99mTc-MDP quantitative SPECT / CT in Chinese people |
| Received:May 11, 2020 Revised:June 15, 2020 Click here to download the full text |
| Citation of this paper:HOUXIAOGUANG,LIUGUOBING,LIUSIWEI,SUNDENGQIN,YUHAOJUN,GUYUSHEN.The normal distribution characteristics of standardized uptake value of spine and pelvis with 99mTc-MDP quantitative SPECT / CT in Chinese people[J].Chinese Journal of Clinical Medicine,2020,27(5):750-755 |
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| Abstract:Objective: To study the normal distribution characteristics of standardized uptake value (SUV) of spine and pelvis with 99mTc-methylene diphosphate (99mTc-MDP) in Chinese people Single Photon Emission Computed Tomography/Computed Tomography (SPECT/CT) imaging. Methods: This retrospective study was performed on 500 enrolled patients with cancer undergoing bone quantitative xSPECT/CT with 99mTc-MDP. The maximum and mean SUV (SUVmax and SUVmean) of were measured. Furthermore, the distribution of SUV in normal bone and its correlation with age, height, weight and the CT value was assessed. Results: The maximum?SUVmax and SUVmean were in the sixth cervical vertebra (7.4 ± 2.4 and 6.0 ± 2.1 respectively), and the minimum in the third sacral vertebra (4.4 ± 2.0 and 2.2 ± 1.1 respectively). The coefficient of variation (CV) of SUVmax and SUVmean in spine and pelvis were similar, ranging from 31.6% to 45.6% and 34.1% to 52.7% respectively. The variation between individuals of SUVmax（CVpelvis = 42.4%, CVspine= 35.0%）and SUVmean (CVpelvis = 52.7% , CVspine = 38.3%) in pelvis were slightly larger than that of spine. There was no significant difference (P>0.05) between male and female. There was no significant correlation between SUVmax and SUVmean of spine and pelvis and height (P > 0.05). In addition, both SUVmax and SUVmean showed negative correlation with age, and positive correlation with weight and CT values. Conclusion: The SUV of 99mTc-MDP in normal bone can be obtained by bone quantitative xSPECT/CT, which can reflect the mineral metabolism of bone and be used as a reference for the diagnosis and evaluation of bone metastasis. There are some differences in the SUV of different parts of bone. The application of SUV in diagnosing and evaluating bone metastasis should be region specified. |
| keywords:: single photon emission computed tomography computed tomography standardized uptake value 99mTc- methylene diphosphate |
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