| Protective effect of Banxiaxiexin decoction on the experimental rats with gastric ulcer caused by acetic acid |
| Received:October 07, 2020 Revised:November 13, 2020 Click here to download the full text |
| Citation of this paper:XU Fei-xiang,GONG Zhen-yu,XUE Ming-ming.Protective effect of Banxiaxiexin decoction on the experimental rats with gastric ulcer caused by acetic acid[J].Chinese Journal of Clinical Medicine,2020,27(6):978-982 |
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| Author Name | Affiliation | E-mail | | XU Fei-xiang | Department of Emergency, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | GONG Zhen-yu | Department of Emergency, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | XUE Ming-ming | Department of Emergency, Zhongshan Hospital, Fudan University, Shanghai 200032, China | xue.mingming@zs-hospital.sh.cn |
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| Abstract:Objective:To explore the effects and mechanism of Banxiaxiexin decoction (BXD) on experimental gastric ulcer in rats.Methods:Forty-eight rats were randomly divided into six groups: normal, control, Omeprazole treatment, low-dose, mid-dose, and high-dose of BXD treatment groups with 8 in each group. Models were established using the improved Okabe method. After modeling, rats in the control group were given 4 mL of normal saline twice a day. Low-dose, mid-dose, and high-dose BXD were administered twice a day by gavage at the dosage of 1, 2, and 4 mL/kg, respectively. Omeprazole (4 mL) was given to models daily at the dosage of 0.36 g/kg. After having been given BXD for 14 days, all groups of rats were sacrificed on the 15th day, the normal gastric condition and the gastric ulcer tissue were examined. Gastric ulcer tissue was evaluated by ulcer index (UI), ulcer inhibition rate, pH of gastric acid, i-NOS, t-NOS, NO in serum, and the expression of VEGF in the ulcer tissue.Results:Compared with the control group, UI in the low/middle/high-dose of BXD group was lower than that in the control group. Ulcer inhibition rate in the low group was higher than that in the model group, the differences were all statistically different (P<0.05), and the ulcer inhibition rate of the high-dose group (P<0.01) was significantly improved than that of the model group when compared with other groups. Moreover, pH of gastric acid, t-NOS, and NO in serum were increased in BXD groups (P<0.05) especially in high dose group (P<0.01) when compared with the model group, while i-NOS in serum was declined, the differences were all statistically different. Compared with the model group, VEGF expressed in gastric ulcer tissue in the low-, medium-, and high-dose of BXD group were promoted, the differences were all statistically different (P<0.05).Conclusions:BXD can significantly promote gastric ulcer healing and its mechanism may be related to the rise of pH of gastric acid, t-NOS, NO in serum and VEGF expressed in gastric ulcer tissue and the decline of i-NOS in serum. |
| keywords:Banxiaxiexin decoction gastric ulcer NOS NO |
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