| Research progress of retinal α-crystallins in proliferative retinal diseases |
| Received:October 31, 2019 Revised:August 19, 2020 Click here to download the full text |
| Citation of this paper:XU Ya-hui,YUAN Yuan-zhi.Research progress of retinal α-crystallins in proliferative retinal diseases[J].Chinese Journal of Clinical Medicine,2020,27(5):866-870 |
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| Abstract:α-crystallins are an important member of the small-molecule heat shock protein family (sHSP), including αA-crystallin and αB-crystallin, which have cytoprotection and molecular chaperone functions in various cells and tissues. In recent years, it has been found that retinal α-crystallins are involved in proliferative retinal diseases via regulating angiogenesis and epithelial/endothelial-mesenchymal transition. This article introduces the specific mechanism of α-crystallins, especially αB-crystallin, in regulating the development of proliferative retinal diseases, and its potential clinical application. |
| keywords:α-crystallins diabetic retinopathy macular degeneration vitreoretinopathy angiogenesis epithelial-mesenchymal transition |
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