| Correlation of serum uric acid before dialysis and all-cause mortality in peritoneal dialysis patients |
| Received:November 15, 2019 Revised:May 07, 2020 Click here to download the full text |
| Citation of this paper:QIU Shan-fang,TENG Jie,SHEN Bo,PEI Juan,CAI Qing-qing,ZHANG Yan-lin.Correlation of serum uric acid before dialysis and all-cause mortality in peritoneal dialysis patients[J].Chinese Journal of Clinical Medicine,2020,27(5):815-821 |
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| Author Name | Affiliation | E-mail | | QIU Shan-fang | Department of Nephrology, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen 361006, Fujian, China
Department of Nephrology, First Affiliated Hospital of Xiamen University, Xiamen 361000, Fujian, China | | | TENG Jie | Department of Nephrology, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen 361006, Fujian, China
Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | SHEN Bo | Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | PEI Juan | Department of Nephrology, First Affiliated Hospital of Xiamen University, Xiamen 361000, Fujian, China | | | CAI Qing-qing | Medical Center of Groningen University, Groningen 9713 KC, Netherlands | | | ZHANG Yan-lin | Department of Nephrology, First Affiliated Hospital of Xiamen University, Xiamen 361000, Fujian, China | zyl59@139.com |
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| Abstract:Objective: To explore the correlation of serum uric acid (UA) level before dialysis and mortality in patients undergoing peritoneal dialysis. Methods: The clinical data of 140 patients with end-stage renal disease (ESRD) treated with PD as the first choice of renal replacement therapy in the First Affiliated Hospital of Xiamen University from January 1, 2001 to December 31, 2017 were retrospectively analyzed. The patients were divided into three groups based on the tertile of uric acid level: low UA group (<387 μmol/L, n=46), middle UA group (387-519 μmol/L, n=44) and high UA group (≥519 μmol/L, n=50). The risk ratio of all-cause death was compared among the three groups, and the survival curve was drawn by the Kaplan-Meier method. Results: For every 20 μmol/L increased in UA, the risk of all-cause death increased by 0.3% (HR=1.003, 95% CI 1.00-1.005, P=0.019). The all-cause mortality in the high UA group was higher than that in the low UA group, HR was 2.3 (95% CI 1.06-5.01, P=0.035), and the value of UA in predicting death risk within 3 years after dialysis was higher. Conclusions: UA may be positively correlated with all-cause mortality in patients undergoing maintenance peritoneal dialysis. The increase of baseline UA may be an independent risk factor for all-cause mortality in those patients indicating that control of the UA level may be helpful to prolong the survival time of patients undergoing peritoneal dialysis. |
| keywords:chronic renal failure peritoneal dialysis uric acid all-cause mortality |
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