| Effects of PPARγ agonists on inflammation and vascular remodeling in COPD rats |
| Received:October 07, 2019 Revised:April 12, 2020 Click here to download the full text |
| Citation of this paper:WANG Chen,LI Zhi,TAN Lin.Effects of PPARγ agonists on inflammation and vascular remodeling in COPD rats[J].Chinese Journal of Clinical Medicine,2020,27(4):670-673 |
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| Author Name | Affiliation | E-mail | | WANG Chen | Intensive Care Unit, Qingdao Municipal Hospital, Qingdao University, Qingdao 266071, Shandong, China | | | LI Zhi | Intensive Care Unit, Qingdao Municipal Hospital, Qingdao University, Qingdao 266071, Shandong, China | | | TAN Lin | Intensive Care Unit, Qingdao Municipal Hospital, Qingdao University, Qingdao 266071, Shandong, China | 1059037278@qq.com |
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| Abstract:Objective: To explore the effects of rosiglitazone hydrochloride on vascular remodeling and IL-8 in rat models of chronic obstructive pulmonary disease(COPD).Methods: Thirty-six Wistar rats were randomized to three groups: non-treatment group (group A), treatment group (group B), and blank group (group C). Rat model of COPD was established in groups A and B by using smoking, hypoxia and intratracheal lipopolysaccharide. The rats in group B were treated with rosiglitazone from week 3, and those in group C were given identical dose of normal saline.Results: The vascular wall pathology showed that the vascular wall remodeling, collagen deposition, and perivascular neutrophils infiltration in group B were alleviated than in group A, but more serious than in group C. The ratio of pulmonary vascular wall/total vascular area in group A were higher than that in groups C and B (P<0.01). The level of IL-8 in group A were higher than in groups C and B (P<0.01). PPARγ mRNA in lung tissue increased in order of groups A, B, and C (P<0.01). Pearson analysis showed that in group B, the levels of PPARγ mRNA were negatively correlated with the ratio of pulmonary vascular wall/total vascular area and the level of IL-8 (r=-0.662 and -0.615, P<0.05).Conclusions: Rosigltazone inhibits the remodeling of the pulmonary vascular wall in COPD rats by upregulating transcription of PPARγ and inhibiting the increase of IL-8 and the infiltration of neutrophils around the vascular wall. |
| keywords:pulmonary disease chronic obstructive vascular remodeling inflammation peroxisome proliferators-actived receptor γ IL-8 |
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