| Clinicopathologic characteristics of lung ciliated muconodular papillary tumor |
| Received:July 17, 2019 Revised:May 08, 2020 Click here to download the full text |
| Citation of this paper:PEI Xiao-yue,FENG Lu,HU Bo,LI Xiao-hui.Clinicopathologic characteristics of lung ciliated muconodular papillary tumor[J].Chinese Journal of Clinical Medicine,2020,27(4):649-653 |
| Hits: 1646 |
| Download times: 995 |
| Author Name | Affiliation | E-mail | | PEI Xiao-yue | Department of Pathology, Dalian University Affiliated Xinhua Hospital, Dalian 116021, Liaoning, China | | | FENG Lu | Department of Pathology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning, China | fenglusd@163.com | | HU Bo | Department of Pathology, Dalian University Affiliated Xinhua Hospital, Dalian 116021, Liaoning, China | | | LI Xiao-hui | Department of Pathology, Dalian University Affiliated Xinhua Hospital, Dalian 116021, Liaoning, China | |
|
| Abstract:Objective: To explore the clinicopathologic features of ciliated muconodular papillary tumors (CMPT). Methods: Eight CMPT patients with complete clinical data were selected from Xinhua Hospital, Dalian University and the First Affiliated Hospital of Dalian Medical University from January 2017 to December 2018, the clinical characteristics, histopathological features, immunophenotype, molecular pathology, and differential diagnosis were analyzed. Results: Among the 8 patients, the ratio of male to female was 1:7, and the mean age was 63.5 years, there was no dominant sex or location. The first symptoms were all lung space occupying found in physical examination, and imaging manifestations were ground-glass opacity (GGO). Histologically, the neoplasm is composed of ciliary cells, basal cells, and mucous cells. Note the lacustrine formation and papillary structures. Immunohistochemistry showed ciliary columnar cells and mucous cells cytokeratin (CK7) (+), thyroid transcription factor-1 (TTF-1) (+), NapsinA (+ or -); Basal cells P63 (+), P40 (+), CK5/6 (+);epidermal growth factor receptor (EGFR) (+) was weakly expressed in most of the tumor cells, and EGFR was detected by AMRS PCR. Exon 19 was absent in 1 of 6 cases (1/6, 1.7%). AB-PAS (+) with mucous staining, and elastic fiber staining showed loss or destruction of the alveolar elastic framework. All cases were treated by surgical resection without recurrence or metastasis. Conclusions: CMPT is a rare benign tumor, which is easy to be misdiagnosed as mucinous adenocarcinoma. By correctly recognizing ciliated cells and the continuous expression of basal cell markers, the misdiagnosis rate of the disease can be reduced. |
| keywords:lung neoplasms ciliated muconodular papillary tumors ciliary cells mucinous cells papillary neoplasms |
| HTML View Full Text View/Add Comment Download reader |
|
|
|