| Cardiac valve calcification and its relationship with serum bone turnover markers in elderly patients with stage 3-5 non-dialysis chronic kidney disease |
| Received:March 15, 2020 Revised:May 11, 2020 Click here to download the full text |
| Citation of this paper:HONG Wei,XIAO Jing,FU Chen-sheng,ZHANG Xiao-li,YE Zhi-bin.Cardiac valve calcification and its relationship with serum bone turnover markers in elderly patients with stage 3-5 non-dialysis chronic kidney disease[J].Chinese Journal of Clinical Medicine,2020,27(4):639-644 |
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| Author Name | Affiliation | E-mail | | HONG Wei | Department of Osteoporosis and Bone Disease, Huadong Hospital, Fudan University, Shanghai 200040, China | | | XIAO Jing | Department of Nephrology, Huadong Hospital, Fudan University, Shanghai 200040, China | | | FU Chen-sheng | Department of Nephrology, Huadong Hospital, Fudan University, Shanghai 200040, China | | | ZHANG Xiao-li | Department of Nephrology, Huadong Hospital, Fudan University, Shanghai 200040, China | | | YE Zhi-bin | Department of Nephrology, Huadong Hospital, Fudan University, Shanghai 200040, China | yezb2013@163.com |
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| Abstract:Objective: The aim of this study is to determine the prevalence of cardiac valve calcification and its relationship with serum bone turnover markers in elderly patients with stage 3-5 non-dialysis chronic kidney disease (CKD). Methods: Totally, 168 elderly inpatients aged 60-93 years with stage 3-5 non-dialysis CKD (80 male, 88 female) were enrolled. Clinical data, serum blood biochemical and bone turnover marker examination results were collected and analyzed. Patients were divided into cardiac valve calcification (VC) group and non-cardiac valve calcification (NVC) group according to the echocardiography results. Results: Age, serum intact parathyroid hormone (iPTH), beta carboxyl-terminal cross-linking telopeptide of type I collagen (β-CTX), and ALP levels in the VC group were significantly higher than those in the NVC group (P<0.05 or P<0.01), whereas the eGFR level was lower than that in the NVC group (P<0.05). Aortic valve calcification was the most common, followed by the mitral valve and tricuspid valve calcification in stage 3-5 CKD elderly patients. The prevalence of aortic calcification in stage 4 and 5 CKD patients (53.06% and 39.75%) was significantly higher than that in stage 3 CKD patients (25.00%, P<0.05), while there was no significant difference in the prevalence of mitral valve calcification (11.11% vs 8.16% vs 18.07%, P>0.05). Binary logistic regression analysis showed that age, eGFR, β-CTX, and iPTH were significantly correlated with cardiac valve calcification (P<0.05). Multivariate logistic regression analysis showed that older age and higher iPTH were independent risk factors for aortic valve calcification (OR=1.102, 95%CI 1.058-1.148, P<0.01; OR=1.004, 95%CI 1.001-1.007, P<0.01). Older age and higher β-CTX were independent risk factors for mitral valve calcification (OR=1.104, 95%CI 1.010-1.206, P<0.05; OR=1.001, 95%CI 1.000-1.002, P<0.05). However, the OR values of iPTH and β-CTX are close to 1, so there were no clinical significance. Conclusions: The prevalence of VC in stage 4-5 non-dialysis CKD elderly patients was high, among which aortic value calcification is the most common. Aging is an independent risk factor for VC in elderly patients with stage 3-5 non-dialysis CKD. The common serum bone turnover markers have little correlation with VC in elderly CKD patients. |
| keywords:chronic kidney disease cardiac valve calcification bone turnover markers elderly |
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