| Diagnostic value of serum calcium and phosphorus levels in progression of bone metastasis of breast cancer during zoledronic acid therapy |
| Received:May 04, 2020 Revised:June 04, 2020 Click here to download the full text |
| Citation of this paper:XU Bei,LI Qian,ZHOU Yu-hong,LIU Tian-shu.Diagnostic value of serum calcium and phosphorus levels in progression of bone metastasis of breast cancer during zoledronic acid therapy[J].Chinese Journal of Clinical Medicine,2020,27(4):635-638 |
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| Author Name | Affiliation | E-mail | | XU Bei | Department of Oncology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | LI Qian | Department of Oncology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | ZHOU Yu-hong | Department of Oncology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | LIU Tian-shu | Department of Oncology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | liu.tianshu@zs-hospital.sh.cn |
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| Abstract:Objective: To investigate the diagnostic value of serum calcium and phosphorus levels in the progression of bone metastasis of breast cancer during zoledronic acid therapy. Methods: The clinical features were collected from breast cancer patients who underwent zoledronic acid therapy and had bone metastasis in Zhongshan Hospital, Fudan University between January 2014 and December 2019. A single sample t-test was performed to analyze the changes in serum calcium and phosphorus levels over time. Results: Forty-two female patients with bone metastasis breast cancer were included, with a mean age of (53.67 ±11.07) years. During zoledronic acid treatment, the serum calcium and phosphorus levels 1 month, 2 months, 3 months and 6 months before progression of bone metastasis were not statistically different from those at the baseline (P>0.05). Conclusions: For breast cancer patients with bone metastasis progression, changes in serum calcium and phosphorus levels may not reflect the progression of bone metastases earlier than imaging examination. |
| keywords:breast cancer bone metastasis serum calcium serum phosphorus zoledronic acid |
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