| Value of metagenomic next-generation sequencing in prevention and control of nosocomial infectious diseases |
| Received:July 07, 2020 Revised:August 15, 2020 Click here to download the full text |
| Citation of this paper:LIN Jia-bing,GAO Xiao-dong,HU Bi-jie,CHEN Xiang.Value of metagenomic next-generation sequencing in prevention and control of nosocomial infectious diseases[J].Chinese Journal of Clinical Medicine,2020,27(4):554-558 |
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| Author Name | Affiliation | E-mail | | LIN Jia-bing | Department of Hospital Infection Management, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | GAO Xiao-dong | Department of Hospital Infection Management, Zhongshan Hospital, Fudan University, Shanghai 200032, China | gaoxd5@vip.sina.com | | HU Bi-jie | Department of Hospital Infection Management, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Department of Infectious Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China | hubijie@vip.sina.com | | CHEN Xiang | Department of Hospital Infection Management, Zhongshan Hospital, Fudan University, Shanghai 200032, China | |
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| Abstract:Objective: To explore the value of metagenomic next-generation sequencing (mNGS) in the prevention and control of nosocomial infectious diseases. Methods: Retrospectively analyzed the data of 5 patients with infectious diseases from January 1, 2018 to December 31, 2019 in Zhongshan Hospital, Fudan University. Compared the results of mNGS and routine microbial culture. Results: Among the 5 selected patients, routine microbial culture were all negative, while the mNGS detected Bacillus anthracis, Vibrio cholerae, Mycobacterium tuberculosis complex, Plasmodium vivax and Plasmodium falciparum, respectively. All the 5 patients were diagnosed with infectious diseases earlier by mNGS, and the control measures of nosocomial infection were adjusted according to the mNGS results. No new cases of nosocomial transmission were found within 30 days of follow-up. Conclusions: The mNGS plays an important role in the early identification and diagnosis of infectious diseases, and plays a good guiding effect for the early intervention of nosocomial infection prevention and control. |
| keywords:metagenomic next-generation sequencing prevention and control of nosocomial infection case series study |
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