| Research progress on mechanisms of sleep rhythm disturbance promoting Alzheimer disease |
| Received:June 26, 2019 Revised:September 20, 2019 Click here to download the full text |
| Citation of this paper:CHEN Xiao-han,LI Peng,XU Yi-xin,ZHUANG Jian-hua,YIN You.Research progress on mechanisms of sleep rhythm disturbance promoting Alzheimer disease[J].Chinese Journal of Clinical Medicine,2020,27(3):520-523 |
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| Author Name | Affiliation | E-mail | | CHEN Xiao-han | Department of Neurology, Changzheng Hospital, Navy Military Medical University, Shanghai 200003, China | | | LI Peng | Department of Neurology, Changzheng Hospital, Navy Military Medical University, Shanghai 200003, China | | | XU Yi-xin | Department of Neurology, Changzheng Hospital, Navy Military Medical University, Shanghai 200003, China | | | ZHUANG Jian-hua | Department of Neurology, Changzheng Hospital, Navy Military Medical University, Shanghai 200003, China | | | YIN You | Department of Neurology, Changzheng Hospital, Navy Military Medical University, Shanghai 200003, China | yinyou179@163.com |
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| Abstract:Patients with cognitive impairment have a high prevalence of sleep disorders with various manifestations, including insomnia, daytime hypersomnia, sleep breathing disorders, abnormal sleep, restless legs syndrome, sleep rhythm disorders, etc. Alzheimer disease (AD) is the most common type of cognitive impairment. About 73% of Chinese AD patients of Han ethnicityare associated with sleep disorders, among which 53% are related to varying degrees of sleep rhythm disorders. Sleep disorders in AD patients are more prominent in the middle and later stages, so the disturbance of sleep rhythm has always been considered as the result of AD-related neurodegenerative changes, such as "sunset phenomenon". However, recent studies have shown that disturbed sleep rhythms may be involved in the initiation of AD. Prospective follow-up studies abroad found that the cognitively normal elderly with disordered sleep rhythm was more prone to AD after 5-10 years. At present, there is still no in-depth research on how sleep rhythm disorder promotes neurodegenerative changes. This paper reviews the researches on AD-related pathology and biomarkers caused by sleep rhythm disorder. |
| keywords:Alzheimer disease sleep rhythm |
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