| Research progress on the role of prostaglandin E2 in ovulation and its mechanism |
| Received:June 24, 2019 Revised:January 10, 2020 Click here to download the full text |
| Citation of this paper:DONG Jun-peng,YANG Fu.Research progress on the role of prostaglandin E2 in ovulation and its mechanism[J].Chinese Journal of Clinical Medicine,2020,27(3):515-519 |
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| Abstract:Prostaglandin E2 (PGE2) is mainly synthesized by granulosa cells and is a key intrafollicular mediator of ovulation in many mammalian species. In ovulation process, luteinizing hormone (LH) sharply increases and induces granulosa cells to synthesize PGE2 via cyclooxygenase-2 (COX-2) and prostaglandin E synthase (PGES). After released to extracellular space, PGE2 combines to the receptor 2 (PTGER2) and PTGER4 on cumulus cells and induces mitogen activated protein kinase (MAPK) phosphorylation, increases the intracellular cAMP level and activates the protein kinase B (PKB) and MAPK pathway, so as to promote the occurrence of ovulation. The abnormal regulation of PGE2 is associated with a variety of ovulatory disorders, such as polycystic ovary syndrome (PCOS) and luteinized unruptured follicle syndrome (LUFS). |
| keywords:prostaglandin follicles ovulation cumulus cells |
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