| Clinicopathological features of single-center hepatocyte nuclear 1A inactivated hepatocellular adenoma |
| Received:February 12, 2020 Revised:May 14, 2020 Click here to download the full text |
| Citation of this paper:HAN Jing,CHEN Ling-li,ZHANG Xin,JI Yuan.Clinicopathological features of single-center hepatocyte nuclear 1A inactivated hepatocellular adenoma[J].Chinese Journal of Clinical Medicine,2020,27(3):457-460 |
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| Author Name | Affiliation | E-mail | | HAN Jing | Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | CHEN Ling-li | Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | ZHANG Xin | Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | JI Yuan | Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | ji.yuan@zs-hospital.sh.cn |
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| Abstract:Objective: To analyze and summarize the clinicopathological features of hepatocyte nuclear 1A (HNF1A) inactivated hepatocellular adenoma (HCA) in order to improve the understanding of this kind of tumor.Methods: 102 cases of HCA diagnosed by surgical resection in Zhongshan Hospital, Fudan University from 2002 to 2017 were collected. After immunohistochemical classification, the relevant clinical data and morphological characteristics of HNF1A inactivated HCA were retrospectively analyzed.Results: 17 cases were HNF1A inactivated HCA. The ratio of female patients to male patients was 13:4, with an average age of 33 years old. All patients had no history of diabetes, glycogen storage diseases and alcohol consumption. 94.1% (16/17) cases were found by hepatic space occupying in physical examination. Most of the tumors were the single nodule(12/17). The majority future of morphology was steatosis(12/17).Conclusions: HNF1A inactivated HCA rarely turns into hepatocellular carcinoma (HCC). In hepatocelluar adenomatosis cases, we should pay attention to tumor heterogeneity and closely follow up. |
| keywords:hepatocellular adenoma hepatocyte nuclear 1A liver fatty acid binding protein |
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