| The effect of PD-1 inhibitor treatment before liver transplantation on posttransplant rejection in liver cancer patients |
| Received:April 30, 2020 Revised:May 22, 2020 Click here to download the full text |
| Citation of this paper:CUI Chun-xiao,YANG Liu-xiao,WANG Ying,HUANG Jun-feng,HUANG Xiao-wu,FAN Jia,ZHOU Jian,WANG Ting.The effect of PD-1 inhibitor treatment before liver transplantation on posttransplant rejection in liver cancer patients[J].Chinese Journal of Clinical Medicine,2020,27(3):444-447 |
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| Author Name | Affiliation | E-mail | | CUI Chun-xiao | Liver Transplantation Intensive Care Unit, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | YANG Liu-xiao | Liver Transplantation Intensive Care Unit, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | WANG Ying | Liver Transplantation Intensive Care Unit, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | HUANG Jun-feng | Liver Transplantation Intensive Care Unit, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | HUANG Xiao-wu | Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | FAN Jia | Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | ZHOU Jian | Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | WANG Ting | Liver Transplantation Intensive Care Unit, Zhongshan Hospital, Fudan University, Shanghai 200032, China | wang.ting@zs-hospital.sh.cn |
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| Abstract:Objective: To observe the effect of PD-1 inhibitor treatment before liver transplantation on posttransplant rejection in liver cancer patients.Methods: The data of 12 patients with liver cancer who received PD-1 inhibitor before liver transplantation between January 1 and December 31, 2019 in Zhongshan Hospital, Fudan University were analyzed. The concentration of tacrolimus in the early postoperative period were detected and the occurrence of rejection after transplantation were observed.Results: The tacroliums concentration at 1week or 2 week after liver transplantation were (5.14±2.68) ng/mL and (8.41±5.73) ng/mL. The incidence of rejection after liver transplantation was only 16.7%(2/12).Conclusions: The incidence of rejection after liver transplantation is not significantly increased in patients with liver cancer who use PD-1 inhibitors before liver transplantation. |
| keywords:liver transplantation PD-1 inhibitor rejection liver cancer |
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