| Evaluation of hemodynamic changes of early atherosclerosis in rabbit aorta by vector flow imaging technology |
| Received:September 16, 2019 Revised:March 12, 2020 Click here to download the full text |
| Citation of this paper:QIU Yi-jie,DONG Yi,HE Wan-yuan,ZHANG Qi,ZHANG Wei-bin,YANG Dao-hui,ZHU Yu-li,CAO Jia-ying,MAO Feng,WANG Wen-ping.Evaluation of hemodynamic changes of early atherosclerosis in rabbit aorta by vector flow imaging technology[J].Chinese Journal of Clinical Medicine,2020,27(3):438-443 |
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| Author Name | Affiliation | E-mail | | QIU Yi-jie | Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | DONG Yi | Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | HE Wan-yuan | Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | ZHANG Qi | Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | ZHANG Wei-bin | Shanghai Institute of Medical Imaging, Shanghai 200032, China | | | YANG Dao-hui | Shanghai Institute of Medical Imaging, Shanghai 200032, China | | | ZHU Yu-li | Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | CAO Jia-ying | Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | MAO Feng | Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | WANG Wen-ping | Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai 200032, China | puguang61@126.com |
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| Abstract:Objective: To explore the change of wall shear stress (WSS) parameter measured by vector flow imaging technology (V Flow) in evaluation of the early hemodynamic changes of aorta atherosclerosis (AS) in rabbit models.Methods: AS models were established by feeding high fat forage in healthy New Zealand rabbits (n=7). After 14 weeks of feeding, the formation of atherosclerotic plaque on the wall of rabbit abdominal aorta was observed by conventional gray-scale ultrasound, the blood flow volume (BFV) and peak systolic velocity (PSV) were measured by color Doppler flow imaging (CDFI), and V Flow was used to observe and measure the anterior and posterior wall WSS values of the rabbit aorta, then once a week. After 34 weeks of feeding, the pathological examination results were used as the gold standard to compare and analyze the dynamic changes of WSS in the formation and development of AS.Results: The pathological results showed that typical fatty streak changes of AS on the wall of rabbit aorta after 34 weeks of high-fat diet, and AS fibrous plaques appeared in the abdominal aorta of rabbits after 37 weeks. The dynamic changes of the anterior and posterior wall of the abdominal aorta with the progression of the AS course were as follows:from 14 weeks, it showed a decreasing trend, from 20/21 to 27 weeks, it showed an increasing trend, and after 27 weeks it gradually decreased. The inflection point values of the WSS maximum (WSSmax) and WSS average (WSSmean) of the anterior and posterior walls of the abdominal aorta were significantly different from the baseline value at week 0 (P<0.05). The inflection points of WSSmax and WSSmean curves were earlier than the PSV and BFV values measured by conventional CDFI.Conclusions: Compared with traditional CDFI, V Flow can predict as plaque and evaluate hemodynamic changes in abdominal aorta, which has potential clinical application value. |
| keywords:vector flow imaging aorta atherosclerosis wall shear stress rabbit |
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