| Ultrasound image characteristic analysis of non-small cell lung cancer patients with supraclavicular lymph node metastasis before and after treatment with anlotinib |
| Received:February 23, 2020 Revised:March 30, 2020 Click here to download the full text |
| Citation of this paper:LIU Qi-zhi,QIANG Hui-ping,LEI Yu-qiong,CHEN Jie,FENG Hui,QIAN Jia-lin,ZHANG Yan-wei,CHU Tian-qing,WU Wei-hua.Ultrasound image characteristic analysis of non-small cell lung cancer patients with supraclavicular lymph node metastasis before and after treatment with anlotinib[J].Chinese Journal of Clinical Medicine,2020,27(3):410-413 |
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| Author Name | Affiliation | E-mail | | LIU Qi-zhi | Department of Ultrasonography, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China | | | QIANG Hui-ping | Department of Ultrasonography, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China | | | LEI Yu-qiong | Department of Ultrasonography, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China | | | CHEN Jie | Department of Ultrasonography, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China | | | FENG Hui | Department of Ultrasonography, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China | | | QIAN Jia-lin | Department of Ultrasonography, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China | | | ZHANG Yan-wei | Department of Ultrasonography, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China | | | CHU Tian-qing | Department of Ultrasonography, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China | ctqxkyy@163.com | | WU Wei-hua | Department of Ultrasonography, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China | liu987@vip.sina.com |
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| Abstract:Objective: To analyze the blood flow characteristics of the supraclavicular lymph nodes metastasis in patients with advanced non-small cell lung cancer by color Doppler ultrasound, these patients were treated with anlotinib as an anti-angiogenic drug, and therefore to provide help for lung cancer patients to evaluate the curative effect of the drug. Methods: From February 2019 to November 2019, clinical data of 31 advanced non-small cell lung cancer patients in the Chest Hospital, Shanghai Jiao Tong University treated with anlotinib were analyzed retrospectively. The two-dimensional color Doppler ultrasonography characteristics of the metastatic lymph nodes on the clavicle before and after two cycles of anlotinib treatment were compared and the correlation was analyzed. Results: The peak systolic velocity (PSV) of supraclavicular lymph node blood flow in patients after the treatment with anlotinib decreased significantly (12.8 cm/s vs 7.5 cm/s), and the difference was statistically significant (P=0.006). Before the treatment, the blood flow classification of supraclavicular lymph nodes in patients with anlotinib was 38.7%, 12.1%, 18.2% and 29.0% in patients with level 3.1% and 41.9% in patients with level 0, and the difference was statistically significant (P=0.029). Before the treatment, 29.0% of the patients had no blood flow distribution in supraclavicular lymph nodes, and 19.4%, 3.2% and 48.4% in central, marginal, and mixed types, respectively. After treatment with anlotinib the proportion of mixed blood flow pattern in supraclavicular lymph nodes decreased to 22.6%(P=0.001) and that of non-blood flow pattern increased to 41.9%. Conclusions: As an antiangiogenic drug, anlotinib has a direct and effective effect on the blood flow of metastatic supraclavicular lymph nodes. The changes of the size and blood flow characteristics of supraclavicular lymph nodes can be used as a criterion for the short-term efficacy of ultrasound in the diagnosis of lung cancer. |
| keywords:ultrasound lung cancer supraclavicular lymph nodes |
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