| Analysis of insulin resistance and pancreatic β cell function in patients with primary aldosteronism |
| Received:April 30, 2020 Revised:June 11, 2020 Click here to download the full text |
| Citation of this paper:XU Jiong,LIU Jun,HUANG Xin-mei,WANG Fang,CHEN Zao-ping,SHENG Li,ZHA Bing-bing,ZANG Shu-fei,WU Yue-yue,YANG Min,ZHANG Rui,LI Yue.Analysis of insulin resistance and pancreatic β cell function in patients with primary aldosteronism[J].Chinese Journal of Clinical Medicine,2020,27(3):386-391 |
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| Author Name | Affiliation | E-mail | | XU Jiong | Department of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China | | | LIU Jun | Department of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China | liujun@5thhospital.com | | HUANG Xin-mei | Department of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China | | | WANG Fang | Department of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China | | | CHEN Zao-ping | Department of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China | | | SHENG Li | Department of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China | | | ZHA Bing-bing | Department of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China | | | ZANG Shu-fei | Department of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China | | | WU Yue-yue | Department of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China | | | YANG Min | Department of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China | | | ZHANG Rui | Department of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China | | | LI Yue | Department of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China | |
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| Abstract:Objective: To explore the insulin sensitivity and pancreatic β cell function in patients with primary aldosteronism (PA).Methods: 95 PA patients and 210 essential hypertension (EH) patients were admitted in Shanghai Fifth People's Hospital, Fudan University from January 2014 to December 2015. The insulin resistance and β cell function in PA and EH patients were analyzed according to the history of diabetes. According to whether the activity of aldosterone to active renin ration (ARR) was greater than 50, PA patients were divided into high PA group (45 cases) and low PA group (50 cases). QUICK index and HOMA-IR were used to evaluate the insulin sensitivity, the HOMA-β cell index and first phase insulin secretion (ΔI30/ΔG30) were used to assess the pancreatic β cell function.Results: Univariate analysis showed that, for patients without history of diabetes, HOMA-β in the high PA group was lower than that in the EH group (P<0.05), and ΔI30/ΔG30 in the high PA and low PA groups was lower than that in the EH group (P<0.05). While for patients with history of diabetes, only HOMA-β in the high PA group was lower than that in the EH group (P<0.05). The results of multiple linear regression showed that, the level of upright plasma aldosterone had a significant negative effect on LnΔI30/ΔG30 in non-diabetic patients (β=-0.375, P<0.05). And the level of upright plasma had significant negative effect on LnHOMA-β in patients with history of diabetes (β=-0.367, P<0.01). Aldosterone level had no significant effect on insulin resistance regardless of diabetes history.Conclusions: The abnormality of glucose metabolism caused by primary hyperaldosteronism may be related to the dysfunction of islet function induced by elevated aldosterone. |
| keywords:primary aldosteronism insulin resistance pancreatic β cell function |
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