Chiness Journal of Clinical Medicine

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Comparison of quantitative T₁ mapping and multi-phase enhanced MRI in evaluating pathological grading of clear cell renal cell carcinoma

Received:November 10, 2019 Revised:December 03, 2019 Click here to download the full text

Citation of this paper:TAN Qin-xuan,DING Yu-qin,DAI Chen-chen,TANG Qi-ying,ZENG Meng-su,ZHOU Jian-jun.Comparison of quantitative T₁ mapping and multi-phase enhanced MRI in evaluating pathological grading of clear cell renal cell carcinoma[J].Chinese Journal of Clinical Medicine,2020,27(1):65-70

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Author Name	Affiliation	E-mail
TAN Qin-xuan	Department of Radiology, Zhongshan Hospital, Fudan University Shanghai Institute of Medical Imaging Department of Medical Imaging, Shanghai Medical College, Fudan University, Shanghai 200032, China
DING Yu-qin	Department of Radiology, Zhongshan Hospital, Fudan University Shanghai Institute of Medical Imaging Department of Medical Imaging, Shanghai Medical College, Fudan University, Shanghai 200032, China
DAI Chen-chen	Department of Radiology, Zhongshan Hospital, Fudan University Shanghai Institute of Medical Imaging Department of Medical Imaging, Shanghai Medical College, Fudan University, Shanghai 200032, China
TANG Qi-ying	Department of Radiology, Xiamen Branch of Zhongshan Hospital, Fudan University, Xiamen 361015, Fujian, China
ZENG Meng-su	Department of Radiology, Zhongshan Hospital, Fudan University Shanghai Institute of Medical Imaging Department of Medical Imaging, Shanghai Medical College, Fudan University, Shanghai 200032, China
ZHOU Jian-jun	Department of Radiology, Zhongshan Hospital, Fudan University Shanghai Institute of Medical Imaging Department of Medical Imaging, Shanghai Medical College, Fudan University, Shanghai 200032, China Department of Radiology, Xiamen Branch of Zhongshan Hospital, Fudan University, Xiamen 361015, Fujian, China	zhou.jianjun@zs-hospital.sh.cn

Abstract:Objective: To compare the value of quantitative T₁ mapping and multi-phase enhanced MRI in differentiating between low- and high-grade clear cell renal cell carcinoma (ccRCC). Methods: Clinical data of ninety-four patients with ccRCC approved by pathological examination were respectively analyzed. All patients underwent T₁ mapping and multi-phase enhanced MRI examination before operation. According to the International Society of Urological Pathology (ISUP) classification criteria, 64 patients were grade Ⅰ-Ⅱ (low-grade group), and 30 patients were grade Ⅲ-Ⅳ (high-grade group). The enhancement rate of corticomedullary phase and nephrographic phase, T₁ values of pre-and post-contrast imaging as well as the T₁ reduction rate were compared between the two groups. The receiver operating characteristic (ROC) analysis was used for the evaluation. Results: The enhancement rate of ccRCC in the high-grade group in corticomedullary phase and nephrographic phase were lower than those in the low-grade group, but there was no significant difference between the two groups. The post-contrast T₁ value increased and T₁ reduction rate decreased in the high-grade group compared with those in the low-grade group (P<0.001). The areas under the ROC curves for the post-contrast T₁ and T₁ reduction rate values to distinguish low- and high-grade ccRCC were 0.855 and 0.828, respectively. Conclusions: Quantitative T₁ mapping is superior to conventional multi-phasic enhanced MRI scanning in differentiating between low- and high-grade ccRCC.

keywords:renal cell carcinoma nuclear grades quantitative analysis T₁ mapping

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