| Clinical study of protective ventilation reducing lung injury in patients with general anesthesia in plateau area |
| Received:October 23, 2019 Revised:January 15, 2020 Click here to download the full text |
| Citation of this paper:ZHANG Zheng,GESANG Luo-bu,BIANBA Wang-dui,CHEN Qi.Clinical study of protective ventilation reducing lung injury in patients with general anesthesia in plateau area[J].Chinese Journal of Clinical Medicine,2020,27(2):293-297 |
| Hits: 1663 |
| Download times: 1299 |
| Author Name | Affiliation | E-mail | | ZHANG Zheng | Department of Anesthesiology, Shanghai United Family Hospital, Shanghai 200335, China | | | GESANG Luo-bu | Department of Anesthesiology, Rikaze People's Hospital, Rikaze 857000, Tibet, China | | | BIANBA Wang-dui | Department of Anesthesiology, Rikaze People's Hospital, Rikaze 857000, Tibet, China | | | CHEN Qi | Department of Anesthesiology and Critical care medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China | 2742559452@qq.com |
|
| Abstract:Objective: To investigate the risk of lung injury associated with perioperative protective mechanical ventilation in patients living in plateau area. Methods: We chose 120 patients from plateau area who would receive general anesthesia, and randomly divided into the protective ventilation group (PV group) and the control ventilation group (CV group). In CV group, we used a tidal volume of 10 mL/kg, no positive end-expiratory pressure (PEEP) or lung re-expansion, ventilation frequency of 12 times/min, and a ratio of 1:2. In PV group, we used a tidal volume of 6 mL/kg, a ventilation frequency of 12 times/min, and a ratio of 1:2, PEEP 6 cmH2O(1 cmH2O=98.066 5 Pa), and did lung re-expansion every half hour. We recorded lung compliance, pulmonary oxygenation index (OI=PaO2/FiO2), alveolar-arterial partial pressure difference (A-aDO2), oxygenation index (PaO2/FiO2), average arterial pressure (MAP), heart rate (HR), and oxygen saturation (SpO2) of the patients at 5 minutes after anesthesia induction(T1), 1 hour after mechanical ventilation(T2), and before extubation (T3) respectively. Results: In PV group, Cdyn and OI at T2 and T3 were significantly increased (P<0.05), and A-aDO2 was significantly decreased (P<0.05). The changes in MAP, HR and SpO2 in the two groups were not statistically significant. There was no significant difference in PaO2 and PaCO2 between the two groups at each time point. The Qs/Qt value of T3 in PV group was significantly lower than that in CV group (P<0.05). Conclusions: Protective ventilation can reduce the risk of lung injury associated with perioperative mechanical ventilation in patients living in plateau area. |
| keywords:lung protective ventilation patients with general anesthesia in plateau area lung injury |
| HTML View Full Text View/Add Comment Download reader |
|
|
|