| Effect of vitamin D supplementation on degree of coronary artery disease |
| Received:August 20, 2019 Revised:November 15, 2019 Click here to download the full text |
| Citation of this paper:ZHOU Xiao-Li,WANG Yi-chun,SHI Hui.Effect of vitamin D supplementation on degree of coronary artery disease[J].Chinese Journal of Clinical Medicine,2020,27(1):60-64 |
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| Author Name | Affiliation | | ZHOU Xiao-Li | Department of Endocrine, Cardiovascular and Cerebrovascular Hospital of General Hospital of Ningxia Medical University, Yinchuan 750000, Ningxia, China | | WANG Yi-chun | Department of Endocrine, General Hospital of Ningxia Medical University, Yinchuan 750000, Ningxia, China | | SHI Hui | Department of Radiological, Cardiovascular and Cerebrovascular Hospital of General Hospital of Ningxia Medical University, Yinchuan 750000, Ningxia, China |
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| Abstract:Objective: To investigate the effect of vitamin D intervention on the Gensini score of coronary arteries in coronary heart disease (CHD) patients and their correlation. Methods: The data of 109 patients underwent coronary artery CT examine were prospective studied. The patients were divided into the control group and the intervention group. Patients in two groups were treated with secondary prevention of CHD. The intervention group was treated with vitamin D calcium tablets orally and vitamin D2 intramuscularly. The changes in clinical indexes and Gensini score of coronary arteries before and after treatment in the two groups were observed. The correlations between clinical indexes, vitamin D and Gensini score of coronary arteries were analyzed. Results: In experimental group, the levels of triacylglycerol (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), serum phosphorus, erythrocyte sedimentation rate (ESR), high-sensitivity C-reactive protein (hs-CRP), and Gensini score after treatment were all lower than before treatment (P<0.05), while the levels of high-density lipoprotein cholesterol (HDL-C), serum calcium, 25(OH)D were higher after treatment than before treatment (P<0.05). The differences of TC, LDL-C, Ca, 25(OH)D, ESR, hs-CRP, and Gensini score in the control group before and after treatment were higher than those in the experimental group (P<0.05). Pearson correlation analysis results showed that there were significant correlations between taking vitamin D supplements or not, age, LDL-C, HDL-C, TC, fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), hs-CRP, 25(OH)D, and Gensini score. The correlation coefficients were -0.519,0.357,0.725,-0.632,0.419,0.290,0.327,0.599, and -0.478, respectively. The multivariate linear correlation analysis results showed that the increases of LDL-C and hs-CRP were risk factors of CHD (Gensini score increased), and taking vitamin D supplements, and the levels of HDL-C and 25(OH)D were protecting factors of CHD (Gensini score decreased). Conclusions: 25(OH)D is negatively correlated with Gensini score of coronary arteries and increasing the level of 25(OH)D may alleviate the severity of CHD. |
| keywords:25(OH)D coronary heart disease Gensini score |
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