Prognostic value of C19orf28 protein expression in gastric cancer |
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Citation of this paper:高其忠,高翔,刘芬,葛晓松.Prognostic value of C19orf28 protein expression in gastric cancer[J].Chinese Journal of Clinical Medicine,2019,26(5):763-766 |
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Abstract:Objective:To investigate whether C19orf28 has prognostic value for patients with gastric cancer (GC). Methods:Immunohistochemical staining (IHC) was used to detect the expression of C19orf28 in 141 GC tissues and adjacent tissues (5 cm from cancer tissue). Results:The expression of C19orf28 in GC tissues was significantly higher than that in adjacent tissues. There was no significant difference in the clinicopathologic features of patients (n=43) with high expression of C19orf28 and those (n=98) with low expression of C19orf28. The overall survival (OS) of patients with high expression of C19orf28 was significantly shorter than that of patients with low expression of C19orf28 (P=0.000 3). The mean survival time of patients with high expression of C19orf28 (23.40 months) was statistically shorter than that of patients with low expression of C19orf28 (38.35 months, P<0.01). Cox multivariate risk regression model analysis results showed that C19orf28 expression (HR=2.34, P=0.005, 95% CI 1.30-4.21) was an independent predictor of poor prognosis in patients with GC. Conclusions:The expression of C19orf28 protein in GC may be related to the poor prognosis of GC patients, and it has potential application value in predicting the prognosis of GC patients. |
keywords:C19orf28 gastric cancer prognosis |
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