| Abstract:Objective：To analyze the correlation between blood routine indexes and liver fat content in patients with type 2 diabetes mellitus complicated with non-alcoholic fatty liver disease (NAFLD). Methods：The hospitalized patients with type 2 diabetes and ultrasound verified NAFLD were selected. Height, weight, waist circumference, hip circumference, blood pressure, blood total cholesterol, triglyceride, low density lipoprotein cholesterol, and fasting and 2 h postprandial blood glucose, liver function, and other parameters were measured. Hepatic fat content was detected by 1H MRS. Results：A total of 641 patients were selected. The average hepatic fat content of all patients was (21.56±17.0)%. The results of Pearson’s/spearman’s correlation analysis showed that serum red blood cell count, hemoglobin concentration, white blood cell count were significantly correlated with the hepatic fat content, in addition to those traditional risk factors. For female patients, the results were similar. However, in male patients, red blood cell count and hemoglobin concentration were correlated with hepatic fat content, instead of white blood cell count. Logistic regression analysis showed that alanine aminotransferase (ALT) and red blood cell count were independent risk factors affecting hepatic fat content, when age, body mass index (BMI) and waist circumference were adjusted. For male patients, serum hemoglobin and ALT were independent risk factors affecting hepatic fat content. For female patients, red blood cell count and ALT were independent risk factors affecting hepatic fat content. Conclusions：Blood routine parameters, such as red blood cell count or hemoglobin concentration may be considered as serum markers reflecting hepatic fat content in type 2 diabetes patients with NAFLD. |