| Angiogenesis and anti-angiogenesis targeted therapy in neurofibroma |
| Received:May 15, 2019 Revised:June 23, 2019 Click here to download the full text |
| Citation of this paper:GU Yihui,REN Jieyi,LI Qingfeng,WANG Zhichao.Angiogenesis and anti-angiogenesis targeted therapy in neurofibroma[J].Chinese Journal of Clinical Medicine,2019,26(5): |
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| Abstract:Neurofibroma is one of the most common clinical manifestations in Neurofibromatosis Type 1, among which plexiform neurofibroma has about 8%-13% risk of malignant transformation. Previous researches suggest that angiogenesis plays an important role in the progression and malignancy of neurofibroma, while the anti-angiogenesis drugs have also demonstrated their potential clinical value in neurofibroma. In this paper, the blood supply characteristics of neurofibroma, the mechanism of angiogenesis and the research progress of anti-angiogenesis targeted therapy in neurofibroma were reviewed. |
| keywords:Neurofibromatosis Angiogenesis Treatment |
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