| Research progress of sufentanil-induced cough response mechanism and preventive drugs |
| Received:May 07, 2019 Revised:September 28, 2019 Click here to download the full text |
| Citation of this paper:XU Zhi-hong,PAN Yan,LIAO Qing-wu.Research progress of sufentanil-induced cough response mechanism and preventive drugs[J].Chinese Journal of Clinical Medicine,2019,26(6): |
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| Abstract:Sufentanil is often used to inhibit the cardiovascular response caused by tracheal intubation during general anesthesia induction, but it can cause cough in patients during injection, severe cough response can increase closed cavity organ pressure in patients. The risk of anesthesia induction for patients with intracranial hypertension and pneumothorax will be increased. The incidence of cough varies from 28% to 65%, a lot of drugs and methods can inhibit sufentanil-induced cough response in different degrees, however, the comparative literature on efficacy is relatively few. The dose for sufentanil induction is different, and the timing of pre-dosing varies from 2-15 minutes, this article will review the preventive medication for sufentanil-induced cough response in recent years, from the mechanism, the influential factors, the dose-response between preventive administration and sufentanil, and the timing of pre-dosing. |
| keywords:sufentanil cough response mechanism influential factors dose-response preventive medication pre-dose timing |
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