| Angiogenesis and anti-angiogenesis targeted therapy in neurofibroma |
| Received:May 15, 2019 Revised:June 24, 2019 Click here to download the full text |
| Citation of this paper:GU Yi-hui,REN Jie-yi,LI Qing-feng,WANG Zhi-chao.Angiogenesis and anti-angiogenesis targeted therapy in neurofibroma[J].Chinese Journal of Clinical Medicine,2019,26(6):931-935 |
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| Author Name | Affiliation | E-mail | | GU Yi-hui | Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China | | | REN Jie-yi | Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China | | | LI Qing-feng | Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China | | | WANG Zhi-chao | Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China | shmuwzc@163.com |
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| Abstract:Neurofibroma has been one of the most common clinical manifestations in neurofibromatosis type 1, among which about 8%-13% has risk of malignant transformation. Previous researches suggest that angiogenesis plays an important role in the progression and malignancy of neurofibroma, while the anti-angiogenesis drugs have also demonstrated their potential clinical value in neurofibroma. In this article, the blood supply characteristics of neurofibroma, the mechanism of angiogenesis, and the research progress of anti-angiogenesis targeted therapy in neurofibroma are reviewed. |
| keywords:neurofibroma angiogenesis treatment |
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