| Diagnostic value of conventional echocardiographic for cardiotoxicity caused by anthracycline chemotherapy drugs |
| Received:September 27, 2018 Revised:November 19, 2019 Click here to download the full text |
| Citation of this paper:LI Ji,GUO Hai-jian.Diagnostic value of conventional echocardiographic for cardiotoxicity caused by anthracycline chemotherapy drugs[J].Chinese Journal of Clinical Medicine,2019,26(6):919-922 |
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| Abstract:Objective: To investigate the diagnostic value of conventional echocardiography for cardiotoxicity caused by anthracycline chemotherapy drugs. Methods: A total of 136 postoperative patients with breast cancer who underwent anthracycline chemotherapy in our hospital from February 2014 to June 2017 were enrolled. Six cycles of pirarubicin+cyclophosphamide+docetaxel chemotherapy were given. At the end of the treatment, patients were divided into cardiotoxicity group (N=48) and no cardiotoxicity group (N=76). The echocardiographic parameters of the patients before and after chemotherapy were compared, and the value of the conventional echocardiographic parameters was analyzed in the early diagnosis of cardiotoxicity. Results: The values of TAPSE, E/A, and E/a in the cardiotoxic group were significantly lower than those in the no cardiotoxicity group (P<0.05). Receiver operating characteristic (ROC) curve analysis showed that the area under the corresponding ROC curve of TAPSE, E/A, and E/e' were 0.917 (0.874, 0.962), 0.902 (0.853, 0.957), and 0.845 (0.823, 0.921), respectively. The cutoff value of TAPSE, E/A, and E/e' were 20.78, 1.19, and 8.59 mm, and the Youden index is 0.842, 0.761, and 0.712, respectively. Conclusions: Conventional echocardiography has certain value in the diagnosis of cardiotoxicity caused by anthracyclines. |
| keywords:conventional echocardiography anthracycline chemotherapy cardiotoxicity |
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