| Diagnostic value of triglyceride to high-density lipoprotein cholesterol ratio in non-alcoholic fatty liver disease in obese adolescents |
| Received:June 24, 2019 Revised:November 19, 2019 Click here to download the full text |
| Citation of this paper:WANG Zhuo-ping,HUANG Ci-you,WANG Wen,YAO Wei-feng.Diagnostic value of triglyceride to high-density lipoprotein cholesterol ratio in non-alcoholic fatty liver disease in obese adolescents[J].Chinese Journal of Clinical Medicine,2019,26(6):875-879 |
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| Author Name | Affiliation | E-mail | | WANG Zhuo-ping | Department of Endocrinology, The Affiliated Wuxi No.2 People's Hospital of Nanjing Medical University, Wuxi 214000, Jiangsu, China | | | HUANG Ci-you | Department of Endocrinology, The Affiliated Wuxi No.2 People's Hospital of Nanjing Medical University, Wuxi 214000, Jiangsu, China | wuxihcy@sina.com | | WANG Wen | Department of Endocrinology, The Affiliated Wuxi No.2 People's Hospital of Nanjing Medical University, Wuxi 214000, Jiangsu, China | | | YAO Wei-feng | Department of Endocrinology, The Affiliated Wuxi No.2 People's Hospital of Nanjing Medical University, Wuxi 214000, Jiangsu, China | |
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| Abstract:Objective: To explore the value of triglyceride to high-density lipoprotein (TG/HDL-C) ratio in the diagnosis of non-alcoholic fatty liver disease (NAFLD) in obese adolescents. Methods: Totally, 114 obese adolescent patients in Wuxi No.2 People's Hospital outpatient or hospitalized from August 2012 to August 2017 were included in this study. Waist circumference (WC), body mass index (BMI), blood pressure (BP), hydrogen proton magnetic resonance data (1H-MRS), serum alanine aminotransferase (ALT), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), fasting blood glucose (FBG) and insulin (INS), and other clinical data were collected. TG/HDL-C and homeostatic model assessment for insulin resistance (HOMA-IR) were calculated. Results: There were no significant differences in age, sex, BMI, TC, WC, diastolic blood pressure, ALT, and FBG between the two groups. The systolic blood pressure and hepatic triglyceride content (HTGC) levels in the high TG/HDL-C group were significantly higher than those in the low TG/HDL-C group (P=0.02 and less, respectively). Multivariate logistic regression analysis showed that TG/HDL-C was an independent risk factor for NAFLD among obese adolescents (OR=5.78, 95% CI 2.23-14.97, P<0.001). TG/HDL-C predicts the area under the receiver operating characteristic (ROC) curve of NAFLD in obese adolescents, with a sensitivity of 72.5% and a specificity of 71.6% at 2.64 as the diagnostic threshold. Conclusions: TG/HDL-C can be used to predict the risk of NAFLD in obese adolescents. |
| keywords:TG/HDL-C obese adolescent non-alcoholic fatty liver disease prevalence risk |
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