| Effects of indoor air pollution on asthma and serum level of miR-155 in children |
| Received:August 14, 2019 Revised:August 27, 2019 Click here to download the full text |
| Citation of this paper:WANG Shi-min,SUN Su-jing,JI Yi-lun.Effects of indoor air pollution on asthma and serum level of miR-155 in children[J].Chinese Journal of Clinical Medicine,2019,26(6):870-874 |
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| Author Name | Affiliation | E-mail | | WANG Shi-min | Department of Pediatrics, Xi'an Fourth Hospital, Xi'an 710000, Shanxi, China | | | SUN Su-jing | Department of Pediatrics, Xi'an Fourth Hospital, Xi'an 710000, Shanxi, China | | | JI Yi-lun | Department of Child Healthcare, Xi'an Fourth Hospital, Xi'an 710000, Shanxi, China | 928561940@qq.com |
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| Abstract:Objective: To explore the relationship between indoor air pollution and asthma in children and its potential molecular mechanism. Methods: A total of 176 healthy subjects were selected as control group and 176 asthmatic children as asthma group. The level of serum miR-155 was detected by real-time fluorescence quantitative polymerase chain reaction (PCR). HCHO, NO2, and particles (PM10, PM2.5, and PM1) were measured. Univariate and multivariate logistic regression analysis were used to evaluate the relationship between air pollutants and asthma risk. Results: The serum level of miR-155 in asthma group was significantly higher than that in control group (P<0.001). Allergy history of Children, breastfeeding history, environmental tobacco smoke history, PM2.5, and HCHO were related to the occured of asthma (P<0.05). The level of serum miR-155 in asthma group was related to the levels of PM2.5 and HCHO in the room (P<0.05), and this relationship was not observed in the control group. Conclusions: The level of serum miR-155 is closely related to the levels of PM2.5 and HCHO in children with asthma. Indoor air pollution aggravates the incidence of asthma in children in Xi'an province of China, and induces change of miR-155 level. |
| keywords:asthma air pollution microRNA-155 |
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