| The optimal inhalation concentrations of nitrous oxide fraction in oxygen for facilitating fast lung collapse during one-lung ventilation in thoracsope surgery |
| Received:August 15, 2019 Revised:October 10, 2019 Click here to download the full text |
| Citation of this paper:Lü Yue-chang,SHI Yu,LIANG Chao,CANG Jing.The optimal inhalation concentrations of nitrous oxide fraction in oxygen for facilitating fast lung collapse during one-lung ventilation in thoracsope surgery[J].Chinese Journal of Clinical Medicine,2019,26(6):862-865 |
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| Author Name | Affiliation | E-mail | | Lü Yue-chang | Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | SHI Yu | Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | LIANG Chao | Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | superwm226@aliyun.com | | CANG Jing | Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | |
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| Abstract:Objective: To investigate the 50% effective concentration (EC50) and 95% effective concentration (EC95) of nitrous oxide (N2O) fraction in oxygen (O2) for fast lung collapse during one-lung ventilation in video-assisted thoracoscopic surgery (VATS). Methods: Thirty-eight consecutive patients undergoing VATS with American Society of Anesthesiologists (ASA) physical status Ⅰ to Ⅱ were selected. All patients underwent lung sequestration by left double-lumen endotracheal. The lung collapse score of each patient was evaluated by the same surgeon 5 minutes after skin incision. The first patient received 30% N2O in O2, and subsequent concentrations were determined by the lung collapse score of the previous patient using Dixon up-and-down method. The testing interval was set at 10%, and the lowest concentration was 10%. The EC50 and EC95 for fast lung collapse of N2O fraction in O2 was analyzed by probabilistic regression analysis. Results: All patients received 50% N2O in O2 showed successfully fast lung collapse. The EC50 and EC95 of N2O fraction in O2 for fast lung collapse was 27.7% (95% confidence interval 19.9%~35.7%) and 48.7% (95% confidence interval 39.0%~96.3%), respectively. Conclusions: In patients with a left double-lumen endotracheal tube undergoing VATS, the EC50 and EC95 of N2O fraction in O2 for fast lung collapse were 27.7% and 48.7%, respectively. |
| keywords:one-lung ventilation lung collapse nitrous oxide thoracoscope |
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