| Correlation between MRI apparent diffusion coefficient value and Ki-67 index in patients with breast cancer |
| Received:July 08, 2019 Revised:October 08, 2019 Click here to download the full text |
| Citation of this paper:GU Lei,XIA Jin-dong,RAO Sheng-xiang,CHEN Cai-zhong.Correlation between MRI apparent diffusion coefficient value and Ki-67 index in patients with breast cancer[J].Chinese Journal of Clinical Medicine,2019,26(6):844-847 |
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| Author Name | Affiliation | E-mail | | GU Lei | Department of Radiology, Central Hospital of Songjiang, Shanghai 201600, China | | | XIA Jin-dong | Department of Radiology, Central Hospital of Songjiang, Shanghai 201600, China | | | RAO Sheng-xiang | Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Imaging Medicine, Shanghai 200032, China | | | CHEN Cai-zhong | Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Imaging Medicine, Shanghai 200032, China | chen.caizhong@zs-hospital.sh.cn |
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| Abstract:Objective: To explore the relationship between MRI apparent diffusion coefficient (ADC) value and Ki-67 index in patients with breast cancer. Methods: The preoperative MRI diffusion weighted imaging (DWI) images (b=0, 800, 1000 s/mm2) of 120 patients with surgically confirmed breast cancer were retrospectively analyzed, and the ADC values were measured. The correlation between the ADC value and Ki-67 index was analyzed. According to the different Ki-67 index, they were divided into group A (low Ki-67 group, n=60) and group B (high Ki-67 group, n=60). ADC values between the two groups were compared and the identification ability of ADC value was analyzed by receiver operating characteristics (ROC) curve. Results: The ADC value of breast cancer was negatively correlated with Ki-67 index (rb value 800=-0.587, rb value 1 000=-0.63, P<0.000 1). Under the same B value, the average ADC value of group B was significantly lower than that of group A (P<0.000 1). When b value was 1 000 s/mm2, the average ADC value was lower than that of 800 s/mm2 in the same group. When the b value was 800 or 1 000 s/mm2, using 1 954.00 or 1 521.00 (10-6 s/mm2) as the critical ADC values respectively, the area under the ROC curve for differential diagnosis of breast cancer in group A and B was 0.91 or 0.94, respectively. The sensitivity was 73.30% or 83.00%, and the specificity was 95.00% or 91.70%, respectively. Conclusions: ADC value has an important predictive value for the expression of Ki-67 index in patients with breast cancer. |
| keywords:breast cancer apparent diffusion coefficient Ki-67 index magnetic resonance imaging |
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