| Correlation between HBB rs35755129 polymorphism and blood glucose and lipid levels in longevity population in Hongshui River Basin of Guangxi in China |
| Received:October 29, 2019 Revised:December 04, 2019 Click here to download the full text |
| Citation of this paper:LI Qi-qi,PAN Shang-ling.Correlation between HBB rs35755129 polymorphism and blood glucose and lipid levels in longevity population in Hongshui River Basin of Guangxi in China[J].Chinese Journal of Clinical Medicine,2019,26(6):834-838 |
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| Author Name | Affiliation | E-mail | | LI Qi-qi | Department of Pathophysiology, School of Pre-clinical Medicine, Guangxi Medical University, Nanning 530021, Guangxi, China | | | PAN Shang-ling | Department of Pathophysiology, School of Pre-clinical Medicine, Guangxi Medical University, Nanning 530021, Guangxi, China | 610090802@qq.com |
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| Abstract:Objective: To explore the relationship between the polymorphism of HBB rs35755129 and blood glucose and lipid levels in longevity population in Hongshui River Basin of Guangxi.Methods: 303 cases of Guangxi Hongshui River Basin population were selected and divided into longevity group ([93.46±3.09] years old, n=107), elderly group ([75.47±4.44] years old, n=68) and young group ([49.18±9.20] years old, n=128). The genotypes of HBB were classified by PCR-Sanger sequencing, and the effects of polymorphism of the gene locus on fasting blood glucose (FBG) and lipid indexes were analyzed.Results: Cholesterol (TC), high-density lipoprotein (HDL), apolipoprotein A (Apo A) and apolipoprotein B (Apo B) in longevity group were lower than those in the elderly group and the young group (P<0.05). In overall, the fasting blood-glucose level of subjects with AA genotype was higher than those with GG/AG genotype, and triglyceride (TG) was lower than those with GG/AG genotype (P<0.05). In the young group, the expression level of locus on FBG and TG were higher than GG/AG genotype (P<0.05). Males AG/GG genotype carriers in total population presented higher TG level than those with AA genotype (P<0.05), while females AG/GG genotype carriers presented lower FBG level than AA genotype, and higher Apo B level than AA genotype (P<0.05). Males AG/GG genotype carriers in longevity group presented lower low-density lipoprotein (LDL) level compared with that in the AA carriers (P<0.05). In the young group, the total FBG level of AG/GG genotype carriers lower than AA genotype, while TG was higher than AA genotype (P<0.05).Conclusions: The polymorphism of HBB rs35755129 genotype is related to blood glucose and blood lipid,but it is influenced by gender factor. The genotype that plays a regulatory role in different life span may be different. |
| keywords:polymorphism fasting blood glucose blood lipid longevity |
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