| Feasibility study on early assessment of prognosis of acute brain injury by bispectral index |
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| Citation of this paper:书国伟，张珏，费智敏.Feasibility study on early assessment of prognosis of acute brain injury by bispectral index[J].Chinese Journal of Clinical Medicine,2019,26(5):750-753 |
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| Abstract:Objective：To analyze the feasibility of using bispectral index (BIS) values to predict outcomes early in patients with acute brain injury (ABI) and study the correlation between extended Glasgow outcome scale (GOSe) scores and BIS. Methods：A prospective and double-blinded study collecting BIS values and GOSe scores was perforned in patients with ABI. Mean BIS value (BISmean) in non-survival, survival, unfavorable, and favorable outcome groups of ABI patients were calculated. Linear regression between BIS values and GOSe scores was constructed. Receiver operating characteristic (ROC) curves predicting non-survival (GOSe score of 2 or less) and unfavorable outcome (GOSe score of 5 or less) were plotted respectively. Results：There were 309 patients selected. BISmean values were significantly different between non-survival and survival groups (27.11±14.68 vs 67.43±15.71, P<0.01) and the same result was found between unfavorable and favorable outcome groups (46.63±15.36 vs 72.31±13.66, P<0.01). There was a significant positive correlation between BIS values and GOSe scores (R=0.759, R2=0.576, P<0.01). Regression equation: GOSe=0.093×BIS-0.288. ROC curve predicting non-survival patiennts showed that area under the curve (AUC) was equal to 0.981 and the optimal cut-off point of BIS value corresponding with the maximum of sensitivity+specificity was 40.7 (sensitivity=0.952, specificity=0.944); ROC curve predicting unfavorable outcome showed that AUC was equal to 0.897 and the optimal cut-off point of BIS value corresponding with the maximum of sensitivity+specificity was 64.1 (sensitivity=0.734, specificity=0.920). Conclusions：BIS value significantly correlates with GOSe score in ABI patients. It is effective that using BIS value to predict outcome of patients with ABI, continuous and real-time BIS monitoring is more meaningful. |
| keywords:acute brain injury extended Glasgow outcome scale bispectral index correlation |
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