| Research progress on mechanisms of fusobacterium nucleatum promoting colorectal cancer |
| Received:March 21, 2019 Revised:December 30, 2019 Click here to download the full text |
| Citation of this paper:LV Zhen-tao,ZHONG Yun-shi,CHEN Tao,ZHOU Ping-hong.Research progress on mechanisms of fusobacterium nucleatum promoting colorectal cancer[J].Chinese Journal of Clinical Medicine,2020,27(1):127-131 |
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| Author Name | Affiliation | E-mail | | LV Zhen-tao | Department of Endoscopy Center, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | ZHONG Yun-shi | Department of Endoscopy Center, Zhongshan Hospital, Fudan University, Shanghai 200032, China | zhongyunshi@yahoo.com | | CHEN Tao | Department of Endoscopy Center, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | ZHOU Ping-hong | Department of Endoscopy Center, Zhongshan Hospital, Fudan University, Shanghai 200032, China | |
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| Abstract:Fusobacterium nucleatum (Fn) has been linked to colorectal cancer (CRC). Several studies showed an overabundance of Fn in human CRC and elucidated the possible mechanisms of Fn involved in CRC in vitro and in mouse models. The mechanisms of Fn involved in CRC carcinogenesis mainly include immune modulation by increasing myeloid-derived suppressor cells and decreasing natural killer cells, toxic effect mediated by FadA, Fap2, and lipopolysaccharide, increasing tumor-associated microRNAs (such as miR-21), and metabolism modulation. This article reviews the mechanisms of Fn in CRC. |
| keywords:colorectal cancer fusobacterium nucleatum mechanisms |
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