| Thyrotoxicosis induced by PD-1 inhibitor: a case report |
| Received:March 06, 2019 Revised:April 29, 2019 Click here to download the full text |
| Citation of this paper:孙潇泱，蒋晶晶，蔡青青，余一祎，刘天舒，高 鑫.Thyrotoxicosis induced by PD-1 inhibitor: a case report[J].Chinese Journal of Clinical Medicine,2019,26(3):511-封三 |
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| Abstract:We report a case of thyrotoxicosis caused by a PD-1 (programmed death-1) inhibitor. The patient was a 45-year-old female diagnosed with metastatic squamous cell carcinoma. She experienced palpitation, hyperhidrosis and increased appetite 18 days after first PD-1 inhibitor pembrolizumab administration. Laboratory examinations showed elevated free triiodothyronine and free thyroxine, indicating autoimmune thyroiditis caused by PD-1 inhibitor. Her clinical symptoms were relieved afterβ-blocker was used. This case suggested us to strengthen the monitoring of thyroid function and antithyroid antibody levels in patients receiving PD-1 inhibitors, especially in the first 1-2 months of treatment and thus to timely identify and treat thyroid dysfunction. |
| keywords:PD-1 inhibitor pembrolizumab thyrotoxicosis thyroiditis |
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