| Effect of metformin for treatment of neuropathic pain induced by sciatic nerve chronic constriction injury in rats |
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| Citation of this paper:WANG Zhi-yao, LI Wei-shan, LI Ai-lun, FANG Fang, CANG Jing*.Effect of metformin for treatment of neuropathic pain induced by sciatic nerve chronic constriction injury in rats[J].Chinese Journal of Clinical Medicine,2019,26(2):200-204 |
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| Abstract:Objective：To evaluate the effect of metformin for treatment of neuropathic pain induced by sciatic nerve chronic constriction injury in rats.
Methods：Forty-eight female SPF Sprague-Dawley rats (age, 7-9 weeks; weight, 180-200 g) were randomly divided into 4 groups (n=12 in each group): control group (Naive group), sham operation group (Sham group), CCI group and CCI + metformin group (Met group). Metformin (45 mg/kg, 2 times every day) was administrated orally from 3 d before to 7 d after operation. The left mechanical paw withdrawal threshold (MWT), thermal paw withdrawal latency (TWL), and number of cold stimulated paw withdrawal were measured before operation (baseline) and 3 d, 7 d, 10 d, 14 d after operation. CatWalk analysis system was used to measure the change in gait of rats in all groups 3 d and 14 d after operation.
Results：Compared with the Naive group, the left MWT, TWL, and TNCW decreased in the CCI and Met groups (P<0.05). Compared with Naive group, print area, mean print intensity, stand time, and stride length of left paw of rats decreased, but swing time increased in the CCI group, and continued to 14 d after operation (P<0.05); The print area, mean print intensity decreased in the Met group; above indexes in the Sham group were unchanged. Compared with the CCI group, the left MWT, TWL, and TNCW increased in Met group (P<0.05). Compared with the CCI group, the print area, mean print intensity, stand time, stride length of left paw of rats improved in the Met group (P<0.05), but the swing time was unchanged.
Conclusions：Metformin can alleviate mechanical hyperalgesia, thermal and cold allodynia in rats with CCI-induced neuropathic pain, and can improve the gait of rats with neuropathic pain. |
| keywords:neuropathic pain chronic constriction injury metformin rats |
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