| Nalmefene suppresses fentanyl-induced cough during general anesthesia induction: a randomized, double-blind, controlled trial |
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| Citation of this paper:CHEN Shi-yu, JIANG Long, CANG Jing, ZHANG Quan*.Nalmefene suppresses fentanyl-induced cough during general anesthesia induction: a randomized, double-blind, controlled trial[J].Chinese Journal of Clinical Medicine,2019,26(2):265-267 |
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| Abstract:Objective：To evaluate the suppressive effects of nalmefene pretreatment on the incidence of fentanyl-induced cough (FIC), and to observe the influence of nalmefene pretreatment on hemodynamic stability during general anesthesia induction.
Methods：A total of 78 patients of American Society of Anesthesiologists(ASA)Ⅰand Ⅱ were enrolled and randomly divided into 3 groups (26 patients in each group). Patients in the 3 groups were ventilated by face mask 2 min (T0) after entering the operating room. Patients in the control group,nalmefene 0.25 group, nalmefene 0.5 group received normal saline, 0.25 μg/kg nalmefene,or 0.5 μg/kg nalmefene 10 mL before anesthesia induction respectively,2 min later(T1), the heart rate (HR), noninvasive blood pressure (NBP), and pulse oxygen saturation(SpO2) were recorded. Patients were then administrated with 4 μg/kg fentanyl within 5 s. The incidence of FIC and the vital signs were recorded 2 min after administration of fentanyl bolus (T2). After T2, patients were administered with 2.5 mg/kg propofol, 0.6 mg/kg rocuronium, and 1.5 mg/kg lidocaine, 90 s later, the intubation was performed (T3). The vital signs were also recorded after T3.
Results：The incidence of cough in the control group was 53.8%, much higher than that in the nalmefene 0.25 group (3.8%,P<0.01) and nalmefene 0.5 group(0%, P<0.01). There was no significant difference in the hemodynamics between the control group and the nalmefene groups in the corresponding time points.
Conclusions：Pretreatment of nalmefene could effectively suppress the FIC during general anesthesia induction, and it might not reverse the effect of opioids on sympathetic response and influencethe hemodynamic stability. |
| keywords:nalmefene fentanyl cough hemodynamics |
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