| Case-control study on risk factors for congenital heart diseases in Yunnan province |
| Click here to download the full text |
| Citation of this paper:CHEN Zhi-song, LI Zhen, ZENG Yong-li, YU Zhuo*.Case-control study on risk factors for congenital heart diseases in Yunnan province[J].Chinese Journal of Clinical Medicine,2019,26(2):181-186 |
| Hits: 1677 |
| Download times: 796 |
|
| Abstract:Objective：To analyze the related risk factors for congenital heart disease (CHD) in Yunnan province.
Methods：The 1-10-year-old children who were diagnosed with CHD by ultrasound and cardiovascular CT were selected as the case group. These children were hospitalized at the First Affiliated Hospital of Kunming Medical University from January 2017 to January 2018. Meanwhile, the children aged 1-10 years old excluded CHD and/or other congenital malformations, with similar age at conception and gestation with the case group, were selected as the control group at the same period from the Department of Pediatrics and the Outpatient Department of Pediatrics. The mothers in the two groups underwent face-to-face interview questionnaire investigation. The family situation, living environment, living habits, working environment, pregnancy history, disease and medication history, negative life events and mental state, dietary nutrition, and so on were investigated. Univariate and multivariate factor logistic regression analysis were performed.
Results：Univariate analysis results showed that passive smoking during early pregnancy, exposure to pesticides during early pregnancy, abnormal pregnancy history, chronic diseases before pregnancy, a cold or a fever during early pregnancy, negative life events during early pregnancy, taking antipyretic and analgesic drugs or antibiotic medicine during early pregnancy were risk factors for CHD. Multivariate factor logistic regression analysis results showed that passive smoking during early pregnancy (OR=2.26, 95%CI 1.12-4.58), abnormal pregnancy history (OR=2.73, 95%CI 1.31-5.69), have a cold during early pregnancy (OR=4.33, 95%CI 2.15-8.70), negative life events during early pregnancy (OR=2.14, 95%CI 1.06-4.32) were the major risk factors for CHD, and regular consumption of milk, egg, meat, and shrimp during pregnancy (OR=0.35, 95%CI 0.15-0.79), supplementation of folic acid, vitamins, and microelements before pregnancy and during pregnancy (OR=0.32, 95%CI 0.16-0.64) were the protective factors for reducing the incidence of CHD (P<0.05).
Conclusions：It is of great significance to prevent and reduce the occurrence of offspring CHD by strengthening the reasonable combination of protein, vitamins, microelements and the like before and during pregnancy, reducing smoke exposure, and reducing the occurrence of colds, negative life events, and adverse pregnancy. |
| keywords:congenital heart diseases risk factors exposure case-control study |
| HTML View Full Text View/Add Comment Download reader |
|
|
|